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A novel molecularly imprinted polymer material for the recognition of ochratoxin A

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Abstract

A novel molecularly imprinted polymer composite material (OTA-MIPs) was prepared by the complexation between a metal–organic framework single-crystal ordered macropore ZIF-8 and a novel dummy template for the selective recognition of ochratoxin A (OTA). First, the structural analog of OTA was synthesized as a dummy template molecule. Then, OTA-MIPs were synthesized on the ZIF-8 surface by thermal polymerization. The as-synthesized OTA-MIPs were characterized by infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and N2 adsorption. The material exhibited a good network structure as well as a high specific surface area and pore size to facilitate the adsorption of target molecules. OTA-MIPs were examined for OTA re-binding properties. The Langmuir model fitted the adsorption data for OTA-MIPs better than the Freundlich model. At the same time, compared to the corresponding non-imprinted (OTA-NIPs) material, OTA-MIPs exhibited a 6.8-fold higher affinity for OTA. The molecular recognition ability of OTA-MIPs was highly specific for OTA compared to structurally similar compounds such as patulin and zearalenone. OTA-MIPs only exhibited a slight downward trend in terms of performance after five times of reuse. These results highlighted their potential for the concentration of OTA from complex food matrices.

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Acknowledgements

This work was financially supported by the Science and Technology Project of Guangdong Province (20180307024), the scientific research project of Shaoguan University (SZ2018KJ03), the National College Students Innovation and Entrepreneurship Training Program (S202010576027, 202110576004) and the Special Fund for Science and Technology Innovation Strategy of Guangdong Province (Special Fund for the "Climbing Plan") (pdjh2020a0530), the Hunan Provincial Innovation Foundation For Postgraduate (CX20201043), the Scientific Research Fund of Hunan Provincial Education Department (19A144) and the Natural Science Foundation of Hunan Province (2019JJ60058, 2020JJ6102).

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Authors and Affiliations

  1. College of Chemistry and Civil Engineering, Shaoguan University, Shaoguan, 512005, Guangdong, China

    Yulin Wang, Yangyang Li, Yiling Luo, Xiuzhen Qiu & Huishi Guo

  2. Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, Hunan, China

    Yulin Wang & Yangyang Li

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  1. Yulin Wang
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  2. Yangyang Li
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  3. Yiling Luo
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  4. Kailian Zhou
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  5. Xiuzhen Qiu
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Contributions

Yulin Wang: Formal analysis, Writing-original draft. Yangyang Li: Formal analysis. Kailian Zhou: Formal analysis. Yiling Luo: Formal analysis. Huishi Guo: Supervision, Writing – review & editing, Funding acquisition. Xiuzhen Qiu: Methodology, Writing-review & editing, Funding acquisition.

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Correspondence to Xiuzhen Qiu or Huishi Guo.

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Wang, Y., Li, Y., Luo, Y. et al. A novel molecularly imprinted polymer material for the recognition of ochratoxin A. J Polym Res 29, 158 (2022). https://doi.org/10.1007/s10965-022-03005-6

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