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Electrospun poly(L-lactic acid) fiber mats containing a crude Garcinia cowa extract for wound dressing applications

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Abstract

Poly(L-lactic acid) (PLLA) fiber mats containing a crude extract of Garcinia cowa Roxb. (GC) were prepared by electrospinning. The extract was introduced at a level of either at 30 or 50 % with respect to the weight of PLLA. The fibers of both the neat and the GC-loaded PLLA fibers were smooth, with average diameters of 0.80–1.13 μm. The characteristics of the release of GC from the GC-loaded PLLA fiber mats were assessed by a total immersion method in acetate or phosphate buffer solution that contained 0.5 % v/v Tween 80 and 3 % v/v methanol (hereafter, A/T/M or P/T/M medium) at either 32 or 37 °C, respectively. The maximum cumulative amount of GC released from the GC-loaded PLLA fiber mats in the P/T/M medium was greater than that released in the A/T/M medium. The antioxidant activity of the GC-loaded PLLA fiber mats, assessed using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, remained even after they had been exposed to a high electrical potential. The antimicrobial activity of the GC-loaded mats was greatest against Straphylococcus aureus ATCC 25923 and Straphylococcus aureus DMST 20654. Lastly, almost all of the GC-loaded PLLA fiber mats, except for those that contained 50 % GC, were found to be nontoxic to normal human dermal fibroblasts.

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Acknowledgments

This work was supported by the Thailand Research Fund (grant number: MRG5380120). We are grateful to Mae Fah Luang University for its partial financial support and allowing us to use its laboratory facilities. The authors acknowledge that they were partially financially supported by the “Integrated Innovation Academic Center: IIAC,” Chulalongkorn University Centenary Academic Development Project, Chulalongkorn University, which was used to procure the electrospinning apparatus used in this work.

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Authors and Affiliations

  1. School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai, 57100, Thailand

    Orawan Suwantong, Porntipa Pankongadisak & Suwanna Deachathai

  2. The Petroleum and Petrochemical College and The Center for Petroleum, Petrochemicals, and Advanced Materials, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand

    Pitt Supaphol

Authors
  1. Orawan Suwantong
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  2. Porntipa Pankongadisak
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  3. Suwanna Deachathai
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  4. Pitt Supaphol
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Correspondence to Orawan Suwantong.

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Suwantong, O., Pankongadisak, P., Deachathai, S. et al. Electrospun poly(L-lactic acid) fiber mats containing a crude Garcinia cowa extract for wound dressing applications. J Polym Res 19, 9896 (2012). https://doi.org/10.1007/s10965-012-9896-3

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  • DOI: https://doi.org/10.1007/s10965-012-9896-3

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