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Controlled loading and release of methylene blue for hydrogen-bonded LbL poly(vinyl pyrrolidone)/poly (acrylic acid) film

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Abstract

The layer-by-layer (LbL) assembled multilayer films are widely used in controlled drug delivery. Here, hydrogen-bonded LbL multilayer films were assembled through alternating deposition of poly(vinylpyrrolidone) (PVPON) and poly(acrylic acid) (PAA) on glass slides. Methylene blue (MB) was used as a model drug to investigate the loading and release ability of the prepared multilayer film. The results showed that the loading rate of MB was greatly influenced by pH value of the dye solution, and the release rate was controlled both by ionic strength and pH value of immersing solution. The result also indicated that the loading and release of MB were reversible and can be repeated many times. It suggested that the PVPON/PAA multilayer film had potential applications in drug delivery and controlled release.

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Acknowledgement

This work was supported by the National Natural Science Foundation of China (50763005) and the Startup Foundation for Doctors of Xinjiang University, China (BS090119).

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Authors and Affiliations

  1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, Xinjiang University, Urumqi, Xinjiang, 830046, China

    Chunrui Ding, Shimei Xu, Jiangli Lin, Xiaoxia Hu, Wenjiao Jian, Jide Wang & Shun Feng

  2. Xinjiang Product Quality Supervision and Inspection Research Institute, Urumqi, Xinjiang, 830011, China

    Chunrui Ding & Jungang Ma

Authors
  1. Chunrui Ding
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  2. Shimei Xu
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  3. Jiangli Lin
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  4. Xiaoxia Hu
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  5. Wenjiao Jian
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  6. Jide Wang
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  7. Jungang Ma
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  8. Shun Feng
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Correspondence to Shun Feng.

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Ding, C., Xu, S., Lin, J. et al. Controlled loading and release of methylene blue for hydrogen-bonded LbL poly(vinyl pyrrolidone)/poly (acrylic acid) film. J Polym Res 19, 9817 (2012). https://doi.org/10.1007/s10965-011-9817-x

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  • DOI: https://doi.org/10.1007/s10965-011-9817-x

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