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Synthesis, Characterization, and In Vitro Study of Dextrin-Coated Bismuth-Doped Manganese Ferrite Nanoparticles (Bio.3Mno.55Fe2O4) as an MRI Contrast Agent

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Abstract

In magnetic resonance imaging (MRI), super paramagnetic nanoparticles can be used as contrast agents, which improve and enhance biological image information at tissue, cellular, or even molecular levels. Application of super paramagnetic iron oxide nanoparticles as a negative contrast agent in MRI has been widely extended. These particles are able to improve contrast of images via changing the relaxation times of the water protons. The main purpose of this study was to synthesize and characterize the dextrin-coated bismuth-doped manganese ferrite (Bio.3Mno.55Fe2O4) NPs, after this these NPs used as a MRI contrast agents. In vitro study was done to discuss the contrast enhancement. In this work, co-precipitation method used to synthesize the dextrin-coated bismuth-doped manganese ferrite (Bio.3Mno.55Fe2O4) nanoparticles. The morphological study, size, structural properties, and magnetic properties of the nanoparticles were investigated by different techniques. These dextrin-coated bismuth-doped manganese ferrite NPs have super paramagnetic behavior with a normal size of 4 ± 0.5 nm measured by transmission electron microscopy (TEM). Measurements of the relaxivities (r2 and r2*) of the NPs were performed in vitro by using MAGICA gel phantom by a 1.5-T MRI system. The novel MRI contrast agent displays a small value cytotoxicity in human body and a large value of r2 and r2* relaxivity rate. These NPs might successfully raise the image contrast in both T2 and T2*-weighted images, but the NPs showed super paramagnetic behavior with contrast enhancement in T2*-weighted images. Thus, it can increase the contrast of tumor imaging and be a favorable MRI contrast agent for cancer theranostic applications.

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Acknowledgments

I wish to acknowledge the Higher Education Commission (HEC) Pakistan for providing us Research facilities for enabling to do this work. I am thankful to Dr. Muhammad Naeem Ashiq, for providing an opportunity to do the project work in Bahauddin Zakariya University, Multan, Pakistan, and giving me all support and guidance which made me complete the project duly. I am extremely thankful to him for providing such nice support and guidance, although he had a busy schedule managing the corporate affairs. I owe my deep gratitude to my respected project guide Dr. Muhammad Naeem Anjum, who took a keen interest on my project work and guided me all along, until the completion of our project work by providing all the necessary information for developing a good system.

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  1. Department of Physics, Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan

    Muhammad Hassan, Ateeque Ur-Rehman, Muhammad Hamid Nazeer, Khizir Farooq, Kanza Ghanzanfar & Muhammad Naeem Anjum

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  1. Muhammad Hassan
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Correspondence to Muhammad Hassan.

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Hassan, M., Ur-Rehman, A., Nazeer, M.H. et al. Synthesis, Characterization, and In Vitro Study of Dextrin-Coated Bismuth-Doped Manganese Ferrite Nanoparticles (Bio.3Mno.55Fe2O4) as an MRI Contrast Agent. J Supercond Nov Magn 33, 859–865 (2020). https://doi.org/10.1007/s10948-019-05264-9

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