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Aqueous-phase biofunctionalized NH2-MIL-53(Al) MOF for biosensing applications

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Abstract

Here, we synthesize an amino-based metal–organic framework (MOF) encompassing NH2-MIL-53(Al) in water using chemical stirring at room temperature. The pendent group on synthesized NH2-MIL-53(Al) was activated using MES buffer. Afterward, biofunctionalization of MOF have been established through conjugation with anti-bovine serum albumin (anti-BSA) using EDC-NHS. Carbodiimide (–CONH2) functional group in Anti-BSA–NH2-MIL-53(Al) conjugate was confirmed through spectroscopic analysis. Importantly, Anti-BSA conjugated MOF was utilized for BSA optical sensing on basis of photoluminescence quenching mechanism in aqueous media. The limit of detection (LOD) was found 1 ppb for BSA. Expectantly, novel anti-BSA-conjugated NH2-MIL-53(Al) will be recognized as a novel material for biomedical applications such as diagnosis, biosensors and drug delivery in near future.

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Acknowledgements

We thank Science and Engineering Research Board (SERB), New Delhi, for funding under ‘Early Carrier Research Grant (Project’s reference no. ECR/2018/001716). We thank Department of Nano Sciences & Material, Central University of Jammu for providing me with all the necessary facilities and permission to complete my project. We thank Prof. Ki Hyun Kim, Department of Civil and Environmental Engineering, Hanyang University, Seoul 04763, Republic of Korea for his suggestions in this paper work.

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Authors and Affiliations

  1. Department of Nano Sciences and Materials, Central University of Jammu, Jammu, 181143, India

    Rajit Sikka & Pawan Kumar

  2. Department of Environmental and Safety Engineering & Department of Energy Systems Research, Ajou University, Suwon, 16499, Republic of Korea

    Jechan Lee

  3. Department of Bioscience, Arctic Research Centre (ARC), Faculty of Science and Technology, Aarhus University, Frederiksborgvej 399, PO Box 358, 4000, Roskilde, Denmark

    Christian Sonne

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  1. Rajit Sikka
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Correspondence to Pawan Kumar.

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Sikka, R., Kumar, P., Lee, J. et al. Aqueous-phase biofunctionalized NH2-MIL-53(Al) MOF for biosensing applications. J Porous Mater 29, 515–522 (2022). https://doi.org/10.1007/s10934-021-01192-z

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