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Poly(vinyl alcohol-co-lactic acid)/Hydroxyapatite Composites: Synthesis and Characterization

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Abstract

There is a wide range of applications where calcium phosphate and hydroxyapatite (HA) are used as biomaterials, e.g. as synthetic bone grafts, coating on metal prostheses (like hip endoprostheses or dental implants) and drug carriers. In the study, the design and synthesis of composites based on poly(vinyl alcohol-co-lactic acid)/hydroxyapatite (PVA-co-LA/HA) with potential for biomedical applications, they are presented. The hydroxyapatite particles were surface-grafted with l(+)-lactic acid in the presence of manganese acetate as catalyst, resulting in modified hydroxyapatite (HAm) with improved capacity of bonding, respectively for the preparation of the composite based on PVA-co-LA/HAm. FT-IR spectra further confirmed the existence of PLA polymer on the surface of HA particles. In synthesis of PVA-co-LA copolymer the different molar ratios PVA/LA (2/1, 1/1, 1/2), toluene/water: 1/2 (as azeotrope solvent mixture) and manganese acetate as catalyst, were used. The composite materials were synthesized in situ with 10 wt% HA, and respectively HAm (reported to PVA and lactic acid components). The composite materials were characterized by FTIR spectroscopy, thermal analyses (DSC, DTG), 1H-NMR spectroscopy, particle size distribution and zeta potential.

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Acknowledgments

This work was supported by CNCSIS–UEFISCSU, project number 466 PNII—IDEI code_995/2009: Researches in the Field of Polymeric Matrices Design for Sensitive Structures Romania.

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Authors and Affiliations

  1. “Petru Poni” Institute of Macromolecular Chemistry, 700487, Iasi, Romania

    Nita Tudorachi & Aurica P. Chiriac

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  1. Nita Tudorachi
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  2. Aurica P. Chiriac
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Correspondence to Aurica P. Chiriac.

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Tudorachi, N., Chiriac, A.P. Poly(vinyl alcohol-co-lactic acid)/Hydroxyapatite Composites: Synthesis and Characterization. J Polym Environ 19, 546–558 (2011). https://doi.org/10.1007/s10924-011-0282-8

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