Abstract
Synthesis and characterization of novel biodegradable, water soluble and optically active DL-malic acid (DMA) and citric acid (CA) copolymers were studied for possible use as antibacterial agents. The copolymers were synthesized by direct bulk melt condensation in the absence of a catalyst above 150 °C. Characterization of obtained copolymers was carried out with the help of infrared absorption spectra, differential scanning calorimetry and thermo gravimetric analysis. The antibacterial activity of copolymers against bacteria was investigated. The results obtained shows the above copolymers possess a broad wound dressing activity against different types of bacteria and may be useful as antibacterial agents.
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Portilla-Arias J, Patil R, Jinwei H, Ding H, Black KL, Garcia-Alvarez M, Muñoz-Guerra S, Ljubimova JY, Holler E (2010) J Nanomaterials 2010:1–8
Braud C, Bunel C, Vert M (1985) Polym Bull 13:4293–4299
Gregoriadis G, Senior J, Trouet A (1982) Targeting of drugs. Plenum Press, New York, London
Planck H, Dauner M, Renardy M (1992) Degradation phenomena on polymeric biomaterials. Springer, Berlin
Albertsson AC, Karlson S (1998) Degradable Polymers (Eds), Huthig and Wepl, Heidelberg
Langer R (2000) Acc Chem Res 33:94–101
Kricheldorf RH, Kreiser-Samders I (1996) Macromol Symp 103:85–89
Bucholz FL (1996) J Chem Ed 73:512–515
Zhang HZ (2009) J Polym Environ 17:286–290
Nijst CL, Bruggeman JP, Karp JM (2007) Biomacromolecules 8:3067–3073
Bruggeman JP, Bettinger CJ, Nijst CLE, Kohane DS, Langer R (2008) Adv Mater 20:1922–1927
Roweton S, Huang SJ, Swift G (1997) J Polym Environ 5:175–181
Portilla-Arias J, Patil R, Jinwei H, Ding H, Keith Black L, Garcıa-Alvarez M, Munoz-Guerra S, Ljubimova YJ, Holler E (2010) J Nanomaterials 2010:1–8
Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R (2007) Langer nature nanotechnology 12:751–760
Lee BS, Fujita M, Khazenzon N, Wawrowsky KA, Wachsmann-Hogiu S, Farkas DL, Black KL, Ljubimova JY, Holler E (2006) Bioconjugate Chem 17:317–326
Djordjevic I, Choudhury* NR, Dutta N, Kumar S (2009) Polymer 50:1682–1691
Yang J, Webb AR, Ameer GA (2004) Advanced Materials 16:511–516
Abd EI-Rehim HA, Mostafa TB, Bashindy A-M (2005) J Macromole Sci 42:853–867
Tran T, Zhang Yi, Gyawali D, Yang J (2009) Recent Patents on Biomedical Engineering 2:216–222
Swift G (1998) Polym Degra Stabil 59:19–24
Jyothi AN (2010) Composite Interfaces 17:165–174
Shi R, Chen D, Liu Q, Yan W, Xiaochuan X, Zhang L, Tian W (2009) Int J Mol Sci 10:4223–4256
Sun Y, Sun GJ (2001) J Appl Polym Sci 81:617–624
Bartholomew B, Dodgson KS, Matcham GWJ, Shaw DJ, White GF (1977) Biochem J 165:575–580
Li X, Li WJ, Yang YL (1999) Spectroscopy Spectral Anal 19:450
Zhao JP, Liu XR, Qiang LS (2006) Thin Solid Films 515:1455–1460
Max J-J, Chapados C (2002) J Phys Chem A 106:6452–6461
Wang A, Yin H, Huihong L, Xue J, Ren M (2009) Tingshun Jiang 25:12736–12741
Singh KA, Pathak LC, Roy SK (2007) Ceramics International 33:1463–1468
Orhan M, Kut D, Gunesoglu C (2009) J Appl Poly Sci 111:1344–1352
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N. Mithil Kumar thanks the University Grants Commission (UGC), Government of India, New Delhi for the partial financial support.
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Kumar, N.M., Varaprasad, K., Reddy, G.R. et al. Biodegradable Water Soluble Copolymer for Antimicrobial Applications. J Polym Environ 19, 225–229 (2011). https://doi.org/10.1007/s10924-010-0265-1
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DOI: https://doi.org/10.1007/s10924-010-0265-1