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Inhibitors of Insulin-like Growth Factor Signaling: A Therapeutic Approach for Breast Cancer

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.

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Abbreviations

ADCC:

antibody-dependent cellular cytotoxicity

AI:

aromatase inhibitor

eIF4E:

eukaryotic translation initiation factor 4E

4EBP1:

eukaryotic translation initiation factor 4E binding protein 1

ER:

estrogen receptor

GH:

growth hormone

GHRH:

growth hormone-releasing hormone

IGF:

insulin-like growth factor

IGFBPs:

IGF binding proteins

IGF1R:

type I IGF receptor

IR:

insulin receptor

IRS:

insulin receptor substrate

MAPK:

mitogen-activated protein kinase

MMTV:

mouse mammary tumor virus

mTOR:

mammalian target of rapamycin

PI3K:

phosphatidylinositol 3′ kinase

PKB:

protein kinase B

PTB:

phosphotyrosine binding

SERM:

selective estrogen receptor modulator

SH2:

Src-homology 2

siRNA:

small interference RNA

WAP:

whey acidic protein

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  1. Department of Medicine and Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St, SE, Minneapolis, MN, 55455, USA

    Deepali Sachdev & Douglas Yee

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  1. Deepali Sachdev
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  2. Douglas Yee
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Correspondence to Deepali Sachdev or Douglas Yee.

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Sachdev, D., Yee, D. Inhibitors of Insulin-like Growth Factor Signaling: A Therapeutic Approach for Breast Cancer. J Mammary Gland Biol Neoplasia 11, 27–39 (2006). https://doi.org/10.1007/s10911-006-9010-8

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