Abstract
The insulin-like growth factor signaling system has been implicated in cancer etiology, progression, and metastasis. This signaling system involves a network of highly related ligands and receptors. Targeting of this system is complex; multiple receptors, including the insulin receptor, are involved. Further, holo- and hybrid receptors must be considered when considering therapeutic strategies. This review will evaluate the signaling pathways mediated by this system.
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Yee, D. (2019). Role of Insulin-Like Growth Factor Receptors in Cancer Signaling. In: Badve, S., Kumar, G. (eds) Predictive Biomarkers in Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-95228-4_22
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DOI: https://doi.org/10.1007/978-3-319-95228-4_22
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