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Biological Synthesis of Monodisperse AuNPs@Damiana with Enhanced Antiseptic Activity Against Gram-Negative Bacteria

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Abstract

Turnera diffusa commonly called Damiana is a wild shrub traditionally used as aphrodisiac, diuretic, and for cancer and diabetes treatments. Its extracts are rich in flavonoid, phenolic, and terpenoid compounds that have been reported as potential reductors for metal ions. In this sense, this study reports a novel and facile method for green gold nanoparticle (AuNPs) synthesis using T. diffusa extracts. The water-soluble organic compounds were obtained by hydrothermal route and the AuNPs@Damiana samples were fully characterized. The results indicated high efficiency of T. diffusa extracts to reduce and stabilize the AuNPs which showed spherical shape, 24 nm diameter, negative surface charge, and high colloidal stability at biological pH and alkaline media. Additionally, its antimicrobial activity was evaluated against Salmonella Enteritidis, Escherichia coli ATCC 8739, and Listeria monocytogenes, showing an enhanced microbial inhibition on Gram-negative bacteria.

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Acknowledgements

This project was supported by CONACYT grants FC/2820. D.Fischer provided editorial services in English.

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Authors and Affiliations

  1. CONACYT-Centro de Investigaciones Biológicas del Noroeste, C.P. 23090, La Paz, B.C.S., Mexico

    Luis Hernandez-Adame

  2. Immunology & Vaccinology Group, Centro de Investigaciones Biológicas del Noroeste, C.P. 23096, La Paz, B.C.S., Mexico

    Luis Hernandez-Adame, Fernando Ruvalcaba, Verónica Sánchez, Martha Reyes-Becerril & Carlos Angulo

  3. Departamento de Física Aplicada, CONACYT-CINVESTAV-IPN Unidad Mérida, C.P. 97310, Mérida, Yucatán, Mexico

    Miguel Ángel Ruíz-Gómez

  4. Department of Pharmacobiology, Universidad de Guadalajara, University Center of Science and Engineering (CUCEI), 1421 Blvd. Marcelino García Barragan, 44430, Guadalajara, Jalisco, Mexico

    Jorge Silva-Jara

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  1. Luis Hernandez-Adame
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  2. Fernando Ruvalcaba
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Correspondence to Carlos Angulo.

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Hernandez-Adame, L., Ruvalcaba, F., Ruíz-Gómez, M.Á. et al. Biological Synthesis of Monodisperse AuNPs@Damiana with Enhanced Antiseptic Activity Against Gram-Negative Bacteria. J Inorg Organomet Polym 31, 4018–4024 (2021). https://doi.org/10.1007/s10904-021-02017-x

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  • DOI: https://doi.org/10.1007/s10904-021-02017-x

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