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Group VA Poly(amine esters) Containing the Antibacterial Ampicillin

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Abstract

Polyester amines were formed from the reaction of the salt of ampicillin with triphenyarsenic, triphenylantimony, and triphenylbismuth dihalides employing the interfacial polycondensation reaction. IR shows the formation of M–OC=O and M–N bands consistent with the proposed polymer formation. Further, IR results are consistent with the repeat units connecting in a somewhat random manner about the metal atom. MALDI MS results give ion fragments to one and two units in length that are consistent with the proposed structure. Polymers were tested for their ability to inhibit the growth of a number of cancer cell lines including prostate, colon, breast (two cell lines) and pancreatic (two cell lines) cancer cell lines with all of the polymers showing ability to inhibit several of the cancer cell lines.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL, 33431, USA

    Charles E. Carraher Jr., Jessica Dorestant & Mohammed H. Al-Huniti

  2. Florida Center for Environmental Studies, Palm Beach Gardens, FL, 33410, USA

    Charles E. Carraher Jr., Jessica Dorestant & Mohammed H. Al-Huniti

  3. Department of Biology, University of Texas Arlington, Arlington, TX, 76010, USA

    Michael R. Roner & Alisa Moric-Johnson

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  1. Charles E. Carraher Jr.
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  2. Michael R. Roner
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  4. Alisa Moric-Johnson
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  5. Mohammed H. Al-Huniti
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Correspondence to Charles E. Carraher Jr. or Michael R. Roner.

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This paper is dedicated to the memory of Prof. Eberhard Neuse, a friend, colleague and dedicated contributor to the science of inorganic and organometallic polymers of biological significance.

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Carraher, C.E., Roner, M.R., Dorestant, J. et al. Group VA Poly(amine esters) Containing the Antibacterial Ampicillin. J Inorg Organomet Polym 25, 400–410 (2015). https://doi.org/10.1007/s10904-014-0050-z

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