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Synthesis, Structural Characterization, and Initial Evaluation as Anticancer Drugs of Dibutyltin Polyamines Derived from Various 4,6-Diaminopyrimidines

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Abstract

A number of diaminopyrimidines have been incorporated into dibutyltin polyamines with molecular weights ranging from 3.5 × 104 to 3.7 × 106 and product yields from 47 to 88%. Infrared spectroscopy is consistent with the inclusion of the diaminopyridines into the polymer backbone with the IR spectroscopy showing the formation of the Sn–N bond as well as the presence of bands from both reactants being present in the polymer. F MALDI MS is also consistent with the products being polymeric and containing units from both the dibutyltin and pyrimidine reactants. The products exhibit good inhibition of cancer cell lines including those derived from human lung, bone, breast, prostrate, and colon cancers. Inhibition occurs within the same concentration range, and lower than that of the most widely employed chemotherapeutic drug, cisplatin.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL, 33431, USA

    Charles E. Carraher Jr. & Amitabh Battin

  2. Florida Center for Environmental Studies, Palm Beach Gardens, FL, 33410, USA

    Charles E. Carraher Jr. & Amitabh Battin

  3. Department of Biology, University of Texas at Arlington, Arlington, TX, 76010, USA

    Kimberly R. Shahi & Michael R. Roner

Authors
  1. Charles E. Carraher Jr.
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  2. Amitabh Battin
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  3. Kimberly R. Shahi
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  4. Michael R. Roner
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Correspondence to Charles E. Carraher Jr..

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Carraher, C.E., Battin, A., Shahi, K.R. et al. Synthesis, Structural Characterization, and Initial Evaluation as Anticancer Drugs of Dibutyltin Polyamines Derived from Various 4,6-Diaminopyrimidines. J Inorg Organomet Polym 17, 631–639 (2007). https://doi.org/10.1007/s10904-007-9159-7

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  • DOI: https://doi.org/10.1007/s10904-007-9159-7

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