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The Development of a 4-aminonaphthalimide-based Highly Selective Fluorescent Probe for Rapid Detection of HOCl

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Abstract

Recently, more and more evidence indicated that intracellular HOCl plays a crucial role in the regulation of inflammation and apoptosis, while excessive HOCl has an impact on human health problems. So, the development of methods for sensitive detection of HOCl is very vital to reveal its various physiological and pathological functions. In this paper, we have described a simple fluorescent probe for selective detection of HOCl, whereas for higher concentrations of other biological important substances, the probe almost does not respond. The experimental results show that the probe can quantitatively determine the range of 0–1 μM HOCl, the detection limit is 0.05 μM. In addition, the probe reacts quickly with HOCl (< 3 s), which is helpful to monitor HOCl in biological system because HOCl is highly reactive and short-lived. The ability of the probe to HOCl enables it to be used to track the HOCl levels in living systems.

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Data Availability

All data contained in the current manuscript and supplementary information are available.

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Funding

This work was supported by [National Natural Science Foundation of China] [51902125, 22106051]; [Jilin Provincial Department of science and technology] [20200901021SF]; [Jilin Province Development and Reform Commission] [2020C036-4]; [The Education Department of Jilin Province] [1564369511081] and [Jilin science and technology bureau][20190104190].

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Authors and Affiliations

  1. Center of Characterization and Analysis, Jilin Institute of Chemical Technology, Jilin, People’s Republic of China

    Xiaodan Zeng, Jie Chen, Zhigang Liu & Mingshuo Ma

  2. School of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, People’s Republic of China

    Shihua Yu

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  1. Xiaodan Zeng
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  2. Jie Chen
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  3. Shihua Yu
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  4. Zhigang Liu
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Contributions

The conception and design of the study were performed by X.D.Z., and M.S.M. Material preparation was performed by J.C. The financial and equipment resources were acquired by Z.G.L., and S.H.Y. The first draft of the manuscript was written by X.D. Z.,and M.S.M., and all authors commented on previous versions of the manuscript.

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Correspondence to Xiaodan Zeng.

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Zeng, X., Chen, J., Yu, S. et al. The Development of a 4-aminonaphthalimide-based Highly Selective Fluorescent Probe for Rapid Detection of HOCl. J Fluoresc 32, 1843–1849 (2022). https://doi.org/10.1007/s10895-022-02996-1

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