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Novel Benzanthrone Aminoderivatives for Membrane Studies

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Abstract

The potential of novel benzanthrone aminoderivatives to trace the changes in physicochemical properties of lipid bilayer has been evaluated. Binding of the dyes to the lipid bilayers composed of zwitterionic phospholipid phosphatidylcholine (PC) and its mixtures with anionic phospholipid cardiolipin (CL) and cholesterol (Chol) was followed by significant quantum yield increase with small blue shift of emission maximum. Analysis of partition coefficients of the dyes under study showed that all aminobenzanthrones possess high lipid-associating ability. The dyes A8 and AM2 proved to be sensitive to the variations in membrane chemical composition responding to the changes in bilayer hydration induced by CL and Chol.

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Authors and Affiliations

  1. Department of Biological and Medical Physics, V.N. Karazin Kharkov National University, 4 Svobody Sq., Kharkov, 61077, Ukraine

    Valeriya M. Trusova, Olga A. Zhytniakivska, Pavel V. Fedorov & Galyna P. Gorbenko

  2. Department of Chemistry and Geography, Faculty of Natural Sciences and Mathematics, Daugavpils University, 13 Vienibas, Daugavpils, LV5401, Latvia

    Elena Kirilova, Inta Kalnina & Georgiy Kirilov

  3. 19-32 Geroyev Truda Str., Kharkov, 61144, Ukraine

    Valeriya M. Trusova

Authors
  1. Valeriya M. Trusova
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  2. Elena Kirilova
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  3. Inta Kalnina
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  4. Georgiy Kirilov
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  5. Olga A. Zhytniakivska
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  6. Pavel V. Fedorov
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  7. Galyna P. Gorbenko
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Correspondence to Valeriya M. Trusova.

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Trusova, V.M., Kirilova, E., Kalnina, I. et al. Novel Benzanthrone Aminoderivatives for Membrane Studies. J Fluoresc 22, 953–959 (2012). https://doi.org/10.1007/s10895-011-1035-8

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  • DOI: https://doi.org/10.1007/s10895-011-1035-8

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