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Hemodynamics and heat transfer in controlled whole-body hyperthermia: modeling of processes

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Journal of Engineering Physics and Thermophysics Aims and scope

The possibilities of describing structural couplings between the organs of a human being subjected to a treatment procedure of controlled whole-body hyperthermia at 43–44°C are considered. The requirements on a model that characterizes changes in the hemodynamics have been formulated, and the interrelations between the models of hemodynamics and heat transfer are shown. As an example of the implementation of the proposed approaches, a system of equations is given that describes heat exchange between an organism and a heat carrier, numerical simulation in the Matlab, toolbox Simulink medium is carried out, and the results of simulation are presented.

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References

  1. F. V. Ballyuzek, M. F. Ballyuzek, V. I. Vilenskii, et al., Controllable Hyperthermia [in Russian], Nevskii Dialekt, St. Petersburg (2001).

    Google Scholar 

  2. S. R. Ash, C. R. Steinhart, M. F. Curfman, et al., Extracorporal whole body hyperthermia treatments for HIV infection and AIDS, ASAIO J., 43, No. 5, 830–838 (1997).

    Article  Google Scholar 

  3. T. Feyerabend, G. J. Wiedemann, and R. Steeves, Advanced non-seminomatous germ cell cancer of the testis with brain metastases: feasibility of additional brain irradiation and whole body hyperthermia plus chemotherapy, Oncol. Rep., 8, No. 2, 219–223 (2001).

    Google Scholar 

  4. H. I. Robins, D. M. Katschinski, W. Longo, et al., A pilot study of melphalan, tumor necrosis factor-alpha and 41.8 degrees C whole-body hyperthermia, Cancer Chemother. Pharmacol., 43, No. 5, 409–414 (1999).

    Article  Google Scholar 

  5. A. M. Westermann, E. A. Grosen, D. M. Katschinski, et al., A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer, Eur J. Cancer, 37, No. 9, 1111–1117 (2001).

    Article  Google Scholar 

  6. A. Zablow, L. M. Shecterle, R. Dorian, et al., Extracorporal whole body hyperthermia treatment of HIV patients, a feasibility study, Int. J. Hyperthermia, 13, No. 6, 577–586 (1997).

    Article  Google Scholar 

  7. R. A. Vertrees, A. Bidani, D. J. Deyo, et al., Venovenous perfusion-induced systemic hyperthermia: hemodynamics, blood flow, and thermal gradients, Ann. Thorac. Surg., 70, No. 2, 644–652 (2000).

    Article  Google Scholar 

  8. E. Lightfoot, Transfer Phenomena in Living Systems [Russian translation], Mir, Moscow (1977).

    Google Scholar 

  9. M. K. Sharp and R. K. Dharmalingham, Development of a hydraulic model of the human systemic circulation, ASAIO J., 45, No. 6, 535–540 (1999).

    Article  Google Scholar 

  10. F. Yamazaki, K. Monji, Y. Sogabe, and R. J. Sone, Cardiac and peripheral vascular responses to head-up tilt during whole body thermal stress, UOEH, 22, No. 2, 147–158 (2000).

    Google Scholar 

  11. N. V. Kinsht and D. N. Kinsht, Mathematical modeling of systemic circulation and heat exchange in whole body hyperthermia (43–44oC), in: Proc. 5th Asian Control Conf. ASCC 2004, 20–23 July, 2004, Melbourne, Australia (2004), pp. 642–647.

  12. O. I. Craciunescu and S. T. Clegg, Pulsatile blood flow effects on temperature distribution and heat transfer in rigid vessels, J. Biomech. Eng., 123, No. 5, 500–505 (2001).

    Article  Google Scholar 

  13. D. N. Kinsht and N. V. Kinsht, Principles of heat transfer modeling in the case of whole body controllable hyperthermia, in: Proc. Int. Conf. “Computation and Information Technologies in Science, Engineering, and Education,” 7–9 October, 2004, Alma-Ata–Novosibirsk (2004), Vol. 9, Pt. II, pp. 342–345.

  14. N. V. Kinsht and D. N. Kinsht, Mathematical simulation of heating a patient in the procedure of controllable whole body hyperthermia, in: Collected papers of the Int. Conf. “Infocommunicational and Computational Technologies in Science, Engineering, and Education,” 28–30 September, 2004, Tashkent (2004), pp. 217–220.

  15. B. Folkov and É. Nil, Blood Circulation [in Russian], Meditsina, Moscow (1976).

    Google Scholar 

  16. P. Johnson, Peripheral Blood Circulation [Russian translation], Meditsina, Moscow (1982).

    Google Scholar 

  17. D. Morman and L. Heller, Physiology of the Cardiovascular System [Russian translation], Piter, St. Petersburg (2000).

    Google Scholar 

  18. N. V. Kinsht, G. N. Gerasimova, and M. A. Kats, Diagnostics of Electric Circuits [in Russian], Énergoatomizdat, Moscow (1983).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Automation and Control Processes, Far-East Branch of the Russian Academy of Sciences, 5 Radio Str., Vladivostok, 690041, Russia

    N. V. Kinsht

  2. Novosibirsk Regional Hospital, Naukograd, Kol’tsovo, Novosibirsk District, 630559, Russia

    D. N. Kinsht

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  1. N. V. Kinsht
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  2. D. N. Kinsht
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Correspondence to D. N. Kinsht.

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Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 81, No. 6, pp. 1188–1197, November–December, 2008.

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Kinsht, N.V., Kinsht, D.N. Hemodynamics and heat transfer in controlled whole-body hyperthermia: modeling of processes. J Eng Phys Thermophy 81, 1232–1241 (2008). https://doi.org/10.1007/s10891-009-0142-8

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  • DOI: https://doi.org/10.1007/s10891-009-0142-8

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