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Morpholinum Sulphate Salt Immobilized Onto Magnetic NPs Catalyzed Sonication Green Synthesis of Dihydropyrimidinones

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Abstract

The green and effective procedure for synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) was carried out from compound involving active methylene group, urea, and various aldehydes by using morpholinum sulphate salt immobilized onto magnetic nanoparticles as an efficient catalyst in ethanol solvent under ultrasound irradiation. Functionalized Fe3O4 as an effective and recyclable nanocatalyst was prepared and characterized using different methods including Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD) techniques. The advantage of this work is the easy separation of the nanocatalyst by using an external magnet, recyclability, non-toxicity, versatility and high stability of the catalyst. Also, low reaction times and excellent yields make the present protocol very useful and attractive for the synthesis of the titled products by ultrasonic irradiation. Furthermore, the products were identified using melting points, FT-IR and 1H NMR, spectroscopic data.

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Acknowledgements

The authors are grateful to the University of Kashan for supporting this work by Grant No. 159148/90.

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  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 87317, Kashan, Iran

    Hourieh-Sadat Oboudatian, Mohsen Moradian & Hossein Naeimi

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  1. Hourieh-Sadat Oboudatian
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Oboudatian, HS., Moradian, M. & Naeimi, H. Morpholinum Sulphate Salt Immobilized Onto Magnetic NPs Catalyzed Sonication Green Synthesis of Dihydropyrimidinones. J Clust Sci 34, 297–309 (2023). https://doi.org/10.1007/s10876-021-02214-1

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