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Synthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles

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Abstract

Arene ruthenium complexes containing long-chain N-ligands L1 = NC5H4–4-COO–C6H4–4-O–(CH2)9–CH3 or L2 = NC5H4–4-COO–(CH2)10–O–C6H4–4-COO–C6H4–4-C6H4–4-CN derived from isonicotinic acid, of the type [(arene)Ru(L)Cl2] (arene = C6H6, L = L1: 1; arene = p-MeC6H4Pri, L = L1: 2; arene = C6Me6, L = L1: 3; arene = C6H6, L = L2: 4; arene = p-MeC6H4Pri, L = L2: 5; arene = C6Me6, L = L2: 6) have been synthesized from the corresponding [(arene)RuCl2]2 precursor with the long-chain N-ligand L in dichloromethane. Ruthenium nanoparticles stabilized by L1 have been prepared by the solvent-free reduction of 1 with hydrogen or by reducing [(arene)Ru(H2O)3]SO4 in ethanol in the presence of L1 with hydrogen. These complexes and nanoparticles show a high anticancer activity towards human ovarian cell lines, the highest cytotoxicity being obtained for complex 2 (IC50 = 2 μM for A2780 and 7 μM for A2780cisR).

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Acknowledgments

Financial support of this work from the Fonds National Suisse de la Recherche Scientifique (Grant no. 200021-115821) is gratefully acknowledged. We also thank the Johnson Matthey Research Centre for a generous loan of ruthenium(III) chloride hydrate.

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Authors and Affiliations

  1. Institut de Chimie, Université de Neuchâtel, 2009, Neuchâtel, Switzerland

    Georg Süss-Fink & Farooq-Ahmad Khan

  2. University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011, Lausanne, Switzerland

    Lucienne Juillerat-Jeanneret

  3. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland

    Paul J. Dyson & Anna K. Renfrew

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  1. Georg Süss-Fink
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  2. Farooq-Ahmad Khan
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  3. Lucienne Juillerat-Jeanneret
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  4. Paul J. Dyson
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  5. Anna K. Renfrew
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Correspondence to Georg Süss-Fink.

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This article is dedicated to Professor Malcolm Chisholm on the occasion of his 65th birthday.

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Süss-Fink, G., Khan, FA., Juillerat-Jeanneret, L. et al. Synthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles. J Clust Sci 21, 313–324 (2010). https://doi.org/10.1007/s10876-010-0298-6

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  • DOI: https://doi.org/10.1007/s10876-010-0298-6

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