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Organometallic Anticancer Compounds: Novel Half-Sandwich Ru(II)- and Co(II)-Arene Complexes, Their Cytotoxicity, and Apoptosis-Inducing Activity in Liver Cancer Cells

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Abstract

Organometallic complexes in many instances are characterised by potential anti-proliferative activity against different types of cancer cells. In particular, half-sandwich Ru(II)–arene and Co(II)-arene complexes exhibit in vitro and in vivo anticancer activity. Here we report synthesis of two organometallic half-sandwich complexes containing diimine ligand, [Ru(η6-p-cymene)(BIAN)Cl](PF6) and [Co(η5-C5Me5)(BIAN)CO](ClO4)2, where η5-C5Me5 is pentmethylcyclopentadiene and BIAN is bis(4-tert-butylphenylimino)acenaphthene. According to gel electrophoresis data, Co(II)-arene complex exhibits higher DNA cleavage activity than Ru(II)-arene complex due to size and charge of complex cation, and both complexes demonstrate maximum degradation of DNA upon activation by UVA light. In vitro cytotoxicity tests of complexes against human lung carcinoma (A549) and human ovarian carcinoma (A2780) cells indicate cytotoxicity of complexes comparable with cis-platin. The morphological studies have revealed that Co-arene complex induces both apoptotic and necrotic cells death.

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REFERENCES

  1. Frezza, M., Hindo, S., Chen, D., Davenport, A., Schmitt, S., Tomco, D., and Ping Dou, Q., Curr. Pharm. Design, 2010, vol. 16, no. 16, p. 1813. https://doi.org/10.2174/138161210791209009.

    Article  CAS  Google Scholar 

  2. Bindoli, A., Rigobello, MP., Scutari, G., Gabbiani, C., Casini, A., and Messori, L., Coord. Chem. Rev., 2009, vol. 253, nos. 11–12, p. 1692. https://doi.org/10.1016/j.ccr.2009.02.026

  3. Milacic, V., Fregona, D., and Dou, Q.P., Histol. Histopathol., 2008, vol. 23, p. 101. https://doi.org/10.14670/HH-23.101.

  4. Ang, W.H., Casini, A., Sava, G., and Dyson, P.J., J. Organomet. Chem., 2011, vol. 696, no. 5 p. 989. https://doi.org/10.1016/j.jorganchem.2010.11.009

  5. Gligorijevic, N., Aranđelovic, S., Filipovic, L., Jakovljevic, K., Jankovic, R., Grguric-sipka, S., Ivanovic, I., Radulovic, S., and Tesic, Z.L., J. Inorg. Biochem., 2012, vol. 108, p. 53. https://doi.org/10.1016/j.jinorgbio.2011.12.002

    Article  CAS  PubMed  Google Scholar 

  6. Bergamo, A., Masi, A., Peacock, A.F., Habtemariam, A., Sadler, P.J., and Sava, G., J. Inorg. Biochem., 2010, vol. 104, no. 1, p.79. https://doi.org/10.1016/j.jinorgbio.2009.10.005

  7. Hong, X.L., Liang, Z.H., and Zeng, M.H., J. Coord. Chem., 2011, vol. 64, no. 21, p. 3792. https://doi.org/10.1080/00958972.2011.628989

  8. Kong, K.V., Leong, W.K., Ng, S.P., Nguyen, T.H., and Lim, L.H., Chem. Med. Chem., 2008, vol. 3, no. 8. p. 1269. https://doi.org/10.1002/cmdc.200800069

    Article  CAS  PubMed  Google Scholar 

  9. Allardyce, C.S. and Dyson, P.J., J. Cluster Sci., 2000, vol. 12, no. 4, p. 563. https://doi.org/10.1023/A:1014294231261

    Article  Google Scholar 

  10. Dragutan, I., Dragutan, V., and Demonceau, A., Molecules, 2015, vol. 20, no. 9, p. 17244. https://doi.org/10.3390/molecules200917244

  11. Jungwirth, U., Kowol, C.R., Keppler, B.K., Hartinger, C.G., Berger, W., and Heffeter, P., Antioxid. Redox Signal., 2011, vol. 15, no. 4, p. 1085. https://doi.org/10.1089/ars.2010.3663

  12. Interrelations between Essential Metal Ions and Human Diseases, Sigel, A., Sigel, H., and Sigel, R.K., Eds., Netherlands: Springer Netherlands; 2013.

  13. Giaccone, G., Herbst, R.S., Manegold, C., Scagliotti, G.V., Rosell, R., Miller, V., Natale, R.B., Schiller, J.H., Von Pawel, J., Pluzanska, A., Gatzemeier, U., Grous, J., Ochs, J.S., Averbuch, S.D., Wolf, M.K., Rennie, P., Fandi, A., and Johnson, D.H., J. Clin. Oncol., 2004, vol. 22, p. 777.

    Article  CAS  Google Scholar 

  14. Liu, H.K.,and Sadler, P.J., Account. Chem. Res., 2011, vol. 44, no. 5, p. 349. https://doi.org/10.1021/ar100140e

  15. Wang, F., Habtemariam, A., van der Geer, E.P., Fernández, R., Melchart, M., Deeth, R.J., Aird, R., Guichard, S., Fabbiani, F.P., Lozano-Casal, P., and Oswald I.D., Proc. Nat. Acad. Sci., 2005, vol. 102, p. 18269. https://doi.org/10.1073/pnas.0505798102

  16. Medicinal Organometallic Chemistry, Jaouen, G. and Metzler-Nolte, N., Eds., Springer-Verlag-Heidelberg., 2010, vol. 32, no. 21.

  17. Ganeshpandian, M., Loganathan, R., Suresh, E., Riyasdeen, A., Akbarsha, M.A., and Palaniandavar, M., Dalton Trans., 2014, no. 43, p. 1203. https://doi.org/10.1039/C3DT51641E

    Article  CAS  PubMed  Google Scholar 

  18. Gopalakrishnan, D., Ganeshpandian, M., Loganathan, R., Bhuvanesh, N.S., Sabina, X.J., and Karthikeyan, J., RSC Adv., 2017, vol. 7, no. 60, p. 37706. https://doi.org/10.1039/C7RA06514K

    Article  CAS  Google Scholar 

  19. Pastuszko, A., Majchrzak, K., Czyz, M., Kupcewicz, B., and Budzisz, E., J. Inorg. Biochem., 2016, vol. 159, p. 133. https://doi.org/10.1016/j.jinorgbio.2016.02.020

  20. Balaji, S., Mohamed Subarkhan, M.K., Ramesh, R., Wang, H., and Semeril, D., Organometallics, 2020, vol. 39, no. 8, p. 1366. https://doi.org/10.1021/acs.organomet.0c00092

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ACKNOWLEDGMENTS

We thank SRM Institute of Science and Technology, Kattankulathur, India for providing research facilities for the characterization of complexes. Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, India is greatly acknowledged for the financial assistance for procuring chemicals and glassware.

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  1. Department of Chemistry, SRM Institute of Science & Technology, Potheri, Kattankulathur Chengalpattu District, 603203, Tamil Nadu, India

    P. Shridhar, S. Purushothaman & M. Ganeshpandian

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  1. P. Shridhar
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  2. S. Purushothaman
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  3. M. Ganeshpandian
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Correspondence to M. Ganeshpandian.

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Shridhar, P., Purushothaman, S. & Ganeshpandian, M. Organometallic Anticancer Compounds: Novel Half-Sandwich Ru(II)- and Co(II)-Arene Complexes, Their Cytotoxicity, and Apoptosis-Inducing Activity in Liver Cancer Cells. Russ J Gen Chem 90, 2170–2175 (2020). https://doi.org/10.1134/S1070363220110249

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