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Selective IgA Deficiency in Children in Israel

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Abstract

IgA deficiency is the most common human primary immune-deficiency. We evaluated the clinical and immunological characteristics of selective IgA deficiency in children in Israel. The study group included 63 children diagnosed with IgA deficiency from 1987 to 2005. Mean follow-up time per child was 10.6 years. Average age at diagnosis was 10.5 years. In one child, the IgA deficiency was transient. Infectious diseases, mainly recurrent pneumonia and ear infection, were common and occurred in 25 patients (39.7%). Allergic diseases were documented in 20 (31.7%) of our patients. Thirteen children (20.6%) had autoimmune diseases. Malignancies were diagnosed in three children (4.8%), an association that has not been reported in previous series. IgA deficiency appears to be a risk factor for infections, allergic diseases, autoimmune conditions, and malignancy.

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Authors and Affiliations

  1. Department of Pediatrics B, Schneider Children’s Medical Center of Israel, Petah Tikva, 49202, Israel

    Vered Shkalim, Vered Hoffer & Ben Zion Garty

  2. Immunology Laboratory, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel

    Yehudit Monselize

  3. Kipper Institute of Immunology, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel

    Nirit Segal & Ben Zion Garty

  4. Department of Human Microbiology, Tel Aviv University, Tel Aviv, Israel

    Israel Zan-Bar

  5. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Vered Shkalim, Yehudit Monselize, Israel Zan-Bar, Vered Hoffer & Ben Zion Garty

Authors
  1. Vered Shkalim
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  2. Yehudit Monselize
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  3. Nirit Segal
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  4. Israel Zan-Bar
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  5. Vered Hoffer
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  6. Ben Zion Garty
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Corresponding author

Correspondence to Ben Zion Garty.

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Shkalim, V., Monselize, Y., Segal, N. et al. Selective IgA Deficiency in Children in Israel. J Clin Immunol 30, 761–765 (2010). https://doi.org/10.1007/s10875-010-9438-x

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  • DOI: https://doi.org/10.1007/s10875-010-9438-x

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