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The IL-17 Family Cytokines in Immunity and Disease

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Abstract

Introduction

Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major players in the immune response to foreign pathogens. In addition, the pathogeneses of a number of inflammatory diseases have been linked to uncontrolled expression of these cytokine pathways.

Discussion

Genetic and biochemical analyses have elucidated the cellular and molecular events triggered by these proteins during an inflammatory response. While significant efforts have been placed on understanding the functions of IL-17A, IL-17F, and IL-17E, the significance of the other family members, IL-17B−D, in inflammation remains to be determined.

Conclusion

This review will focus on the cellular sources, target cell/receptors that are utilized by these cytokines to control pathogenesis, and the therapeutic potential of targeting these pathways to treat inflammatory disorders.

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Abbreviations

RA:

rheumatoid arthritis

MS:

multiple sclerosis

IBD:

inflammatory bowel disease

NKT:

natural killer T

S. aureus :

Staphylococcus aureus

M. tuberculosis :

Mycobacterium tuberculosis

CIA:

collagen-induced arthritis

EAE:

experimental autoimmune encephalomyelitis

DSS:

dextran sulfate sodium

N. brasiliensis :

Nippostrongylus brasiliensis

MOG:

myelin oligodendrocyte glycoprotein

DC:

dendritic cell

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  1. Department of Immunology, Genentech, Inc., 1 DNA Way, MS, 34, South San Francisco, CA, 94080, USA

    Rajita Pappu, Vladimir Ramirez-Carrozzi, Naruhisa Ota, Wenjun Ouyang & Yan Hu

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  1. Rajita Pappu
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  2. Vladimir Ramirez-Carrozzi
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  3. Naruhisa Ota
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  4. Wenjun Ouyang
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  5. Yan Hu
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Correspondence to Rajita Pappu.

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Pappu, R., Ramirez-Carrozzi, V., Ota, N. et al. The IL-17 Family Cytokines in Immunity and Disease. J Clin Immunol 30, 185–195 (2010). https://doi.org/10.1007/s10875-010-9369-6

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