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The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders

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Abstract

Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17F shows the highest homology to IL-17A among the IL-17 family and binds to the same IL-17 receptor A (IL-17RA) and IL-17RC receptor complex as IL-17A. Recent studies have demonstrated that IL-17A and IL-17F are also produced by multiple lineages of immune cells, including γδ T cells, NKT cells, and innate lymphoid cells. These cytokines are involved in the development of inflammation, autoimmunity, allergy, and tumors, and also play important roles in host defenses against bacterial and fungal infections. However, it is now clear that IL-17A and IL-17F have overlapping—yet distinct—roles in innate and adoptive immune responses. Here, we describe the recent data on the roles of IL-17A and IL-17F in inflammatory disorders and host defense and discuss the potential of these molecules as therapeutic targets.

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Acknowledgements

This work was supported by PRESTO, Japan Science and Technology Agency (S.N.). H.I. is a Postdoctoral Fellow supported by a Postdoctoral Fellowship for Research Abroad from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA

    Harumichi Ishigame

  2. Frontier Research Initiative, Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato, Tokyo, 108-8639, Japan

    Susumu Nakae

  3. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama, Japan

    Susumu Nakae

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  1. Harumichi Ishigame
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Correspondence to Susumu Nakae .

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  1. Department of Immunoregulation Institute of Medical Science, Tokyo Medical University, Tokyo, Tokyo, Japan

    Takayuki Yoshimoto

  2. Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

    Tomohiro Yoshimoto

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Ishigame, H., Nakae, S. (2014). The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders. In: Yoshimoto, T., Yoshimoto, T. (eds) Cytokine Frontiers. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54442-5_3

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