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Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds

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Abstract

Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly(octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn2+) and gallium (Ga3+) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated using a bovine bone model. Scaffolds containing bioactive glass exhibited antibacterial activity and this increased in vitro with higher bioactive glass loads; viable cells decreased to about 20 % for the composite scaffold containing 30 % bioactive glass. The Ga3+ release rate increased as a function of time and Zn2+ was shown to incorporate into the surrounding bone.

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Acknowledgments

This research is supported by a High Impact Research Grant (UM.C/625/1/HIR/MOHE/ENG/58) from the Ministry of Higher Education Malaysia and University of Malaya Research Grant (UMRG, RG156-12AET).

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Authors and Affiliations

  1. Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Ehsan Zeimaran, Sara Pourshahrestani, Ivan Djordjevic, Belinda Pingguan-Murphy, Nahrizul Adib Kadri & Mark R. Towler

  2. Inamori School of Engineering, Alfred University, Alfred, NY, USA

    Anthony W. Wren

  3. Department of Mechanical and Industrial Engineering, Faculty of Engineering and Architectural Science, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada

    Mark R. Towler

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  1. Ehsan Zeimaran
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Zeimaran, E., Pourshahrestani, S., Djordjevic, I. et al. Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds. J Mater Sci: Mater Med 27, 18 (2016). https://doi.org/10.1007/s10856-015-5620-2

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