Abstract
Surface modification on titanium was carried out in order to improve its bioactivity. Pure titanium was hydrothermally treated in distilled water and 0.1 M MgCl2 solutions at 200°C for 24 h. Surface morphology, roughness, wettability and chemical composition were characterized before and after treatment. Bovine serum albumin was used as model to study protein adsorption. MC3T3-E1 cells were cultured and initial cell attachment, morphology, proliferation were evaluated. After hydrothermal treatment, nano-sized precipitations were observed and samples showed superhydrophilicity. Magnesium (Mg) was immobilized into titanium surface by hydrothermal treatment. Protein adsorption was significantly increased on Mg-containing samples. Cell attachment was improved and cell spreading was enhanced on Mg-containing samples compared with untreated or those treated in distilled water. Increased early cellular attachment on the MgTi surface resulted in subsequent increase of number of proliferated cells. Hydrothermal treatment in MgCl2 solution was expected to be an effective method to fabricate titanium implant with good bioactivity.
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This study was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, as well as by the China Scholarship Council (CSC, No. 2009642007).
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Shi, X., Nakagawa, M., Kawachi, G. et al. Surface modification of titanium by hydrothermal treatment in Mg-containing solution and early osteoblast responses. J Mater Sci: Mater Med 23, 1281–1290 (2012). https://doi.org/10.1007/s10856-012-4596-4
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DOI: https://doi.org/10.1007/s10856-012-4596-4