Abstract
In order to obtain early and good osteointegration after implantation of a titanium implant in the human body, the surface modified treatments using NaOH or H2O2 etc. were reported. In this study, titanium was hydrothermally treated with CaCl2 solutions at 200 ∘C for 24hr (CaCl2-HT). Scanning electron microscope (SEM) observation clearly showed apatite deposition on the surface of CaCl2 HT treated titanium faster than other chemical treated titanium immersion in simulated body fluid. X-ray photoelectron spectroscopy (XPS) analysis demonstrated that Ti–O–Ca bonding was formed on titanium surface by hydrothermal treatment with CaCl2 solution. And it was revealed that thickness of TiO2, which was known to play important roles for the formation of bone-like apatite, became approximately three times thicker than as-polished titanium. The amount of initial attached MC3T3-E1 cells on as-polished and NaOH, H2O2 and this CaCl2 HT treated titanium were almost the same values. After 5 days incubation, the growth rate of MC3T3-E1 cells on CaCl2-HT treated titanium was significantly higher than that on other chemical treated titanium. The hydrothermal treatment with 10–20 mmol/L CaCl2 solution at 200 ∘C was an effective method for the fabrication of titanium implant with good bioactivity and osteoconductivity.
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Nakagawa, M., Zhang, L., Udoh, K. et al. Effects of hydrothermal treatment with CaCl2 solution on surface property and cell response of titanium implants. J Mater Sci: Mater Med 16, 985–991 (2005). https://doi.org/10.1007/s10856-005-4753-0
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DOI: https://doi.org/10.1007/s10856-005-4753-0