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Prolonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres

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Abstract

Porous scaffolds that can prolong the release of bioactive factors are urgently required in bone tissue engineering. In this study, PLGA/gelatin composite microspheres (PGMs) were carefully designed and prepared by entrapping poly(l-lactide-co-glycolide) (PLGA) microspheres (PMs) in gelatin matrix. By mixing PGMs with PLGA solution directly, drug-loaded PLGA/carbonated hydroxyapatite (HAp)/PGMs composite scaffolds were successfully fabricated. In vitro release of fluorescein isothiocyanate-dextran (FD70S) as a model drug from the scaffolds as well as PMs and PGMs was studied by immersing samples in phosphate buffered saline (pH = 7.4) at 37°C for 32 days. Compared with PMs, PGMs and PLGA/HAp/PGMs scaffolds exhibited slow and steady release behavior with constant release rate and insignificantly original burst release. The swelling of PGMs, diffusion of drugs, and degradation of polymer dominated the release behaviors synergistically. The PLGA/HAp/PGMs scaffold offers a novel option for sequential or simultaneous release of several drugs in terms of bone regeneration.

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Acknowledgment

This work was supported by Natural Science Foundation of China via grant Nos. 30828008 and 51073117 and also by the Scientific Research Foundation of Graduate School of Tianjin University.

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Authors and Affiliations

  1. School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China

    Gongwen Tang, Hong Zhang, Yunhui Zhao, Xiao Li & Xiaoyan Yuan

  2. Department of Mechanical Engineering, Faculty of Engineering, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong

    Min Wang

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  1. Gongwen Tang
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  2. Hong Zhang
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  3. Yunhui Zhao
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  4. Xiao Li
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  5. Xiaoyan Yuan
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  6. Min Wang
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Correspondence to Xiaoyan Yuan.

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Tang, G., Zhang, H., Zhao, Y. et al. Prolonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres. J Mater Sci: Mater Med 23, 419–429 (2012). https://doi.org/10.1007/s10856-011-4493-2

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  • DOI: https://doi.org/10.1007/s10856-011-4493-2

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