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Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering

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Abstract

One of the most important challenges in composite scaffolds is pore architecture. In this study, poly (3-hydroxybutyrate) with 10% bioglass nanoparticles was prepared by the salt leaching processing technique, as a nanocomposite scaffold. The scaffolds were characterized by SEM, FTIR and DTA. The SEM images demonstrated uniformed porosities of appropriate sizes (about 250–300 μm) which are interconnected. Furthermore, higher magnification SEM images showed that the scaffold possesses less agglomeration and has rough surfaces that may improve cell attachment. In addition, the FTIR and DTA results showed favorable interaction between polymer and bioglass nanoparticles which improved interfaces in the samples. Moreover, the porosity of the scaffold was assessed, and the results demonstrated that the scaffold has uniform and high porosity in its structure (about 84%). Finally it can be concluded that this scaffold has acceptable porosity and morphologic character paving the way for further studies to be conducted from the perspective of bone tissue engineering.

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Authors and Affiliations

  1. Biomaterial Group, School of Metallurgy and Materials Engineering, Iran University of Science and Technology (IUST), Narmak, Tehran, Iran

    Hadi Hajiali, Mohammad Hosseinalipour & Hamid Reza Rezaie

  2. Medical Physics and Biomedical Engineering Group, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran

    Saeed Karbasi

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  1. Hadi Hajiali
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  2. Saeed Karbasi
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Correspondence to Saeed Karbasi.

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Hajiali, H., Karbasi, S., Hosseinalipour, M. et al. Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering. J Mater Sci: Mater Med 21, 2125–2132 (2010). https://doi.org/10.1007/s10856-010-4075-8

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