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Fabrication of mesoporous calcium silicate/calcium phosphate cement scaffolds with high mechanical strength by freeform fabrication system with micro-droplet jetting

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Abstract

In this study, we explored the feasibility of fabrication bioactive mesoporous calcium silicate/calcium phosphate cements (MCS/CPC) scaffolds with high mechanical strength by Freeform Fabrication System with Micro-Droplet Jetting. After preparation of ordered mesoporous calcium silicate (MCS) powder, ready-to-use MCS/CPC paste was formed by mixing calcium phosphate cement (CPC) powder and MCS powder with the binder polyvinyl alcohol (PVA) aqueous solution at a certain ratio of powder to liquid. MCS/CPC scaffolds with various architectures, pore sizes, and interconnectivity were then directly printed at room temperature using MCS/CPC paste. The mechanical strength, apatite formation, degradation rate, and cytocompatibility of the composite scaffolds were systematically investigated. The results showed that MCS/CPC paste exhibited outstanding printability to form MCS/CPC scaffolds. The hybrid MCS/CPC scaffolds with predefined pore size of 350 μm showed fast degradation rate, high mechanical strength, and good cytocompatibility. It was indicated that the hybrid MCS/CPC scaffolds might be a promising candidate for critical bone defect repair.

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Acknowledgements

This investigation was supported by the National Basic Research Program of China (973 Program: 2012CB933600), National Natural Science Foundation of China (No. 31370960, No. 31100678), National Science & Technology Pillar Program during the Twelfth Five-years Plan Period (No. 2012BAD32B01).

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Authors and Affiliations

  1. The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

    Cuidi Li, Li Gao, Fangping Chen & Changsheng Liu

  2. Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

    Fangping Chen & Changsheng Liu

  3. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

    Cuidi Li & Li Gao

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  1. Cuidi Li
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Correspondence to Fangping Chen or Changsheng Liu.

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Li, C., Gao, L., Chen, F. et al. Fabrication of mesoporous calcium silicate/calcium phosphate cement scaffolds with high mechanical strength by freeform fabrication system with micro-droplet jetting. J Mater Sci 50, 7182–7191 (2015). https://doi.org/10.1007/s10853-015-9244-1

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  • DOI: https://doi.org/10.1007/s10853-015-9244-1

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