Abstract
Nanocrystalline hydroxyapatite (HAP) particles were synthesized at room temperature using reverse microemulsions, in which cyclohexane was used as the organic phase, mixed surfactant with TX-100 and 1- pentanol, and CaCl2 solution as aqueous phase. The reactor systems with aqueous/organic volumetric ratios 1:10, 1:5, 2:5, and 1:2 were carefully selected for the microemulsion processing by the pseudo-ternary phase diagram and the electric conductivity measurement of the emulsion. The as-obtained HAP nanoparticles with carbonate substitution and broadening X-ray diffraction (XRD) traces were similar to the fine powder of human bone, despite of the aqueous/organic volumetric ratio in the emulsion. No obvious other’s phase occurred after as-obtained particles calcined under different temperature till 700 °C. In the emulsion-derived precursors, the HAP particles based on spherical morphology were prepared into the size between 15 ∼ 30 nm as a low volumetric ratio of 1:10 or 1:5 was applied. As the volumetric ratio increased to 2:5, the HAP particles with rod-like shape of (140∼280) × (10∼80) nm were formed. Practical implication of the results is that the nanocrystalline bone-like hydroxyapatite can be obtained via the emulsion processing at room temperature without further calcinations.
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References
Aoki H (1994) In: Medical application of hydroxyapatite. IShiyaku EuroAmerica Inc., Tokyo, St.Loui p 10
Hench LL (1991) J Am Ceram Soc 74:1487
Suchanek W, Yoshimura M (1998) J Mater Res 13:765
Takagi O, Kuramoto N, Ozawa M (2004) Ceram Int 30:139
Benmoussa A, Mikou M, Lacout JL, Siouffi AM (1995) J Chromatogr A 694:486
Jang KH, Song KB, Kim JS, Kim CH, Chung BH, Rhee SK (2000) Bioprocess Biosyst Eng 23:89
Lange FF (1989) J Am Ceram Soc 72:3
Ruys AJ, Wei M, Sorrelli CC, Dickson MR, Brandwood A, Milthorpe BK (1995) Biomaterials 16:409
Sonoda K, Furuzono T, Walsh D (2002) Solid State Ionics 151:32
Zhao F, Graysona WL, Ma T, Bunnellb B, Lu WW (2006) Biomaterials 27:1859
Sun JS, Wu YH, Lin FH (2005) Biomaterials 26:3953
Kim HW, Kim HE, Salih V (2005) Biomaterials 26:5221
Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T (1990) J Biomed Mater Res 24:721
Rao RR, Roopa HN, Kannan TS (1997) J Mater Sci Mater Med 8:511
Tas AC, Korkusuz F, Timicin M, Akkas N (1997) J Mater Sci Mater Med 8:91
Rhee SH, Tanaka J (1998) J Am Ceram Soc 81:3029
Wang F, Li MS, Lu YP, Qi YX (2005) Mater Lett 59:916
Ioku K, Kawachi G, Sasaki S (2006) J Mater Sci 41:1341. doi:10.1007/s10853-006-7338-5
Lim GK, Wang J, Ng SC, Gan LM (1996) Mater Lett 28:431
Koumoulidis GC, Katsoulds AP (2003) J Colloid Interface Sci 259:254
Bose S, Susanta KS (2003) Chem Mater 15:4464
Chen CW, Riman RE, Techuisen KS, Brown K (2004) J Cryst Growth 270:615
Guo GS, Sun YX, Wang ZH, Guo HY (2005) Ceram Int 31:869
Qi L, Ma JM, Cheng HM, Zhao ZG (1997) J Mater Lett 16:1779
Lam AC, Schechter RS (1987) J Colloid Interface Sci 120:42
Jillavenkatesa A, Condrate RA Sr (1998) J Mater Sci 33:4111. 10.1023/A:1004436732282doi:10.1023/A:1004436732282
Zhan YJ, Zheng CL, Liu YK, Wang GH (2003) Mater Lett 57:3265
Luo Q, Zhao XH, Zhou G (2004) Chem J Chinese U 25:1085
Lim GK, Wang J, Ng SC, Chew CH, Gan LM (1997) Biomaterials 18:1433
Lai C, Tang SQ, Wang YJ, Wei K (2005) Mater Lett 59:210
Layrolle P, Ito A, Tateishi T (1998) J Am Ceram Soc 81:1421
Kensaku S, Tsutomu F, Dominic W, Sato K, Tanaka J (2002) Solid State Ionics 151:321
Acknowledgements
This work was supported by the national key project program of China (No.1999054306) and program of ministry of science and technology in China (2001AA625050) to Pro. Changren Zhou.
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Li, H., Zhu, M., Li, L. et al. Processing of nanocrystalline hydroxyapatite particles via reverse microemulsions. J Mater Sci 43, 384–389 (2008). https://doi.org/10.1007/s10853-007-2182-9
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DOI: https://doi.org/10.1007/s10853-007-2182-9