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Evaluation of the abilities of γ-cyclodextrin to form complexes by surface plasmon resonance with a Biacore® system

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Abstract

Although phase-solubility studies have often been used to evaluate the interaction of cyclodextrins (CDs) with various drugs, hundreds of milligrams of both CD and drug are required to prepare a phase diagram. A method that would require considerably less material for evaluating complex formation between a CD and guest compound is therefore needed. We previously reported the detection of the interactions between β-CD and various drugs using a Biacore® system. In this study, we succeeded in immobilizing 6-monodeoxy-6-monoamino-γ-CD on the gold surface of a sensor chip and in detecting the interactions between the immobilized γ-CD and various drugs. The interaction processes were kinetically analyzed using Biacore®. The surface plasmon resonance sensorgrams indicated that the association and dissociation rates of the interactions between γ-CD and drugs were faster than those between β-CD and drugs. Although the association constants calculated from the sensorgrams were smaller than those calculated from phase-solubility studies, good correlation was shown between these data.

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Acknowledgements

This work was supported in part by a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Department of Physical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan

    Kazuki Abe, Noriko Ogawa, Hiromasa Nagase, Tomohiro Endo & Haruhisa Ueda

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  1. Kazuki Abe
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  2. Noriko Ogawa
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  3. Hiromasa Nagase
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  4. Tomohiro Endo
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  5. Haruhisa Ueda
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Correspondence to Tomohiro Endo.

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Abe, K., Ogawa, N., Nagase, H. et al. Evaluation of the abilities of γ-cyclodextrin to form complexes by surface plasmon resonance with a Biacore® system. J Incl Phenom Macrocycl Chem 70, 385–388 (2011). https://doi.org/10.1007/s10847-010-9883-4

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  • DOI: https://doi.org/10.1007/s10847-010-9883-4

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