Abstract
Complexation between methyl β-cyclodextrin (Me βCD) and sulconazole nitrate (SULC) was realized both under freeze drying and ultrasonication conditions. The process was carried out in solution and in solid state. In solution, the complexation was evaluated using solubility studies, nuclear magnetic resonance spectroscopy (1H-NMR) and UV–Vis absorption studies. In the solid state, differential scanning calorimetry (DSC), and X-ray diffraction studies were used. Solubility studies indicate the existence of inclusion complexes between SULC and Me βCD. 1H-NMR data showed that the inclusion complexes have different structures, according with the method we used for synthesis: for the freeze dried method the complex is obtained by complexation of dichlorobenzene ring of SULC into inner cavity of CD while for ultrasonication method the complex is obtained by complexation of imidazole graph of SULC into the CD molecule. DSC and X-ray studies bring supplementary information concerning the formation of complex Me βCD–SULC. As a result of the inclusion process into Me βCD, the solubility of SULC increase significant, being 10 times more comparative with the pure drug. We anticipate that these modifications will have a significant impact on the biological effects of the drug, making the SULC–Me βCD complex an appropriate candidate for a new drug delivery system.
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This work was financially supported by CEeX grant 2D11-106 (CICLOMED).
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Spulber, M., Pinteala, M., Fifere, A. et al. Water soluble complexes of methyl β-cyclodextrin and sulconazole nitrate. J Incl Phenom Macrocycl Chem 62, 135–142 (2008). https://doi.org/10.1007/s10847-008-9448-y
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DOI: https://doi.org/10.1007/s10847-008-9448-y