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Synthesis of Novel Chiral C 2-symmetric Diaza-18-crown-6 Ether Derivatives and their Enantioselective Recognition of Amino Acid Derivatives

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Abstract

New chiral diaza-18-crown-6 ether derivatives, 5 and 6 were synthesized from (R)-(-)-2-amino-1-bütanol. These chiral artificial receptors exhibit pronounced chiral recognition toward the enantiomers of l- and d- amino acid derivatives. The highest enantioselectivity was observed in the case of Trp-OMe·HCl (K D /K L =12.5).

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Authors and Affiliations

  1. Faculty of Science, Department of Chemistry, University of Dicle, 21280, Diyarbakır, Turkey

    Yılmaz Turgut, Nadir Demirel & Halil Hoşgören

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  1. Yılmaz Turgut
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  2. Nadir Demirel
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  3. Halil Hoşgören
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Correspondence to Yılmaz Turgut.

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Turgut, Y., Demirel, N. & Hoşgören, H. Synthesis of Novel Chiral C 2-symmetric Diaza-18-crown-6 Ether Derivatives and their Enantioselective Recognition of Amino Acid Derivatives. J Incl Phenom Macrocycl Chem 54, 29–33 (2006). https://doi.org/10.1007/s10847-005-3125-1

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  • DOI: https://doi.org/10.1007/s10847-005-3125-1

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