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Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

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Abstract

An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment.

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Funding

This work was supported in part by a scholarship the Foundation for Research Support of the State of São Paulo (FAPESP, grant number 2015/21907-0, Brazil) to PAN.

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Authors and Affiliations

  1. Division of Human Reproduction, Department of Gynecology and Obstetrics, Ribeirão Preto School of Medicine, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, CEP: 14049-900, Brazil

    M. G. Da Broi, V. S. I. Giorgi & P. A. Navarro

  2. Department of Obstetrics and Gynecology, Laboratory of Reproductive Medicine, NYU School of Medicine, 180 Varick Street, New York, NY, 10014, USA

    F. Wang & D. L. Keefe

  3. Department of Obstetrics and Gynecology, New York University, Langone Medical Center, New York, NY, 10016, USA

    D. L. Keefe

  4. The Center for Human Reproduction, New York, NY, USA

    D. Albertini

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  1. M. G. Da Broi
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  2. V. S. I. Giorgi
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  3. F. Wang
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  4. D. L. Keefe
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  5. D. Albertini
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  6. P. A. Navarro
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Correspondence to P. A. Navarro.

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Da Broi, M.G., Giorgi, V.S.I., Wang, F. et al. Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications. J Assist Reprod Genet 35, 735–751 (2018). https://doi.org/10.1007/s10815-018-1143-3

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  • DOI: https://doi.org/10.1007/s10815-018-1143-3

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