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A greater number of euploid blastocysts in a given cohort predicts excellent outcomes in single embryo transfer cycles

  • Assisted Reproduction Technologies
  • Published:
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Abstract

Purpose

This multicentered retrospective study analyzed whether the quantity of euploid blastocysts in a given cohort after comprehensive chromosomal screening can be used to identify candidates for single embryo transfer.

Methods

Blastocysts from 437 patients underwent trophectoderm biopsy followed by array comparative genomic hybridization. Embryos were then selected for single or double embryo transfer. The number of euploid blastocysts produced and transferred for each patient was recorded, as was clinical pregnancy rate and multiple gestation rate.

Results

In patients with ≤3 euploid blastocysts, clinical pregnancy rate was higher in double, compared to single embryo transfers. However, in patients with ≥4 euploid blastocysts, clinical pregnancy rate was not reduced with single embryo transfer was performed, whereas the multiple gestation rate was greatly reduced.

Conclusions

Size of the euploid embryo cohort is a marker for success in single embryo transfer cycles. Patients who produce at least four euploid blastocysts are outstanding candidates for single embryo transer.

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Acknowledgments

We would like to thank our referral centers for their assistance with the collection of data. The referral centers who contributed to this work are ART Reproductive Center (Beverly Hills, CA), San Diego Fertility Center (San Diego, CA), La Jolla IVF (La Jolla, CA), Stanford Fertility Clinic (Stanford, CA), Acacio Fertility Center (Laguna Niguel, CA), OriginElle Fertility Clinic (Montreal, Quebec), NewLIFE – New Leaders in Fertility and Endocrinology (Pensacola, FL), Reproductive Biology Associates (Atlanta, GA), Georgia Reproductive Specialists (Atlanta, GA), Fertility Centers of Illinois (Highland Park, IL), Boston IVF (Waltham, MA), Fertility Center of Las Vegas (Las Vegas, NV), NYU Fertility Center (New York, NY), Oregon Reproductive Medicine (Portland, OR), and Main Line Fertility and Reproductive Medicine (Bryn Mawr, PA).

Author information

Authors and Affiliations

  1. Obstetrics and Gynecology, NYU Langone Medical Center, 530 1st Ave Rm 9E2, New York, NY, 10016, USA

    Scott Morin

  2. Genesis Fertility, 1355 84th St., Brooklyn, NY, 11228, USA

    Katherine Melzer-Ross

  3. NYU Fertility Center, 660 1st Ave, 5th Floor, New York, NY, 10016, USA

    David McCulloh & Jamie Grifo

  4. Reprogenetics, 3 Regent St., Livington, NJ, 07039, USA

    Santiago Munné

Authors
  1. Scott Morin
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  2. Katherine Melzer-Ross
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  3. David McCulloh
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  4. Jamie Grifo
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  5. Santiago Munné
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Corresponding author

Correspondence to Scott Morin.

Additional information

Capsule This multicentered studied demonstrates that patients who produce ≥4 euploid embryos have equivalent clinical pregnancy rates whether one or two embryos is replaced.

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Morin, S., Melzer-Ross, K., McCulloh, D. et al. A greater number of euploid blastocysts in a given cohort predicts excellent outcomes in single embryo transfer cycles. J Assist Reprod Genet 31, 667–673 (2014). https://doi.org/10.1007/s10815-014-0217-0

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  • DOI: https://doi.org/10.1007/s10815-014-0217-0

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