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Patient selection criteria for blastocyst transfers in extended embryo culture programs

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To identify the correlation between different cycles, patient factors and blastocyst characteristics.

Methods

The study included 420 patients undergoing ICSI cycles and 2781 graded blastocysts, which took into account the blastocyst quality. The correlations between the blastocyst parameters and the patient and cycle characteristics were assessed.

Results

The blastocyst development was negatively correlated with the maternal age, BMI and dose of FSH. The ICM was negatively correlated with the FSH dose, whereas the TE quality was influenced by the FSH dose, the maternal age and the number of retrieved oocytes. The embryo morphology on days two and three may predict the blastocyst developmental competence.

Conclusions

Older patients and patients with high BMI should not be included in extended embryo culture programmes. The extended culture may not favour embryos with poor morphology on days two and three of development. Additionally, a lower ovarian stimulation and decreased oocyte yields may lead to the development of high-quality blastocysts.

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Authors and Affiliations

  1. Fertility–Centro de Fertilização Assistida, Av. Brigadeiro Luis, 4545, São Paulo, SP, 01401-002, Brazil

    Daniela Paes Almeida Ferreira Braga, Amanda S Setti, Rita de Cássia S. Figueira, Assumpto Iaconelli Jr. & Edson Borges Jr.

  2. Instituto Sapientiae–Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo, SP, 04203-040, Brazil

    Daniela Paes Almeida Ferreira Braga, Amanda S Setti & Edson Borges Jr.

  3. Faculdade de Medicina de Jundiaí, Jundiaí, Brazil

    Rogério Bonassi Machado

Authors
  1. Daniela Paes Almeida Ferreira Braga
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  2. Amanda S Setti
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  3. Rita de Cássia S. Figueira
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  4. Rogério Bonassi Machado
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  5. Assumpto Iaconelli Jr.
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  6. Edson Borges Jr.
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Correspondence to Edson Borges Jr..

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Capsule

Older patients and patients with high BMI should not be included in extended embryo culture programmes. Moreover, lower ovarian stimulation and decreased oocyte yields lead to the development to high quality blastocysts.

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Braga, D.P.A.F., Setti, A.S., de Cássia S. Figueira, R. et al. Patient selection criteria for blastocyst transfers in extended embryo culture programs. J Assist Reprod Genet 29, 1357–1362 (2012). https://doi.org/10.1007/s10815-012-9875-y

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  • DOI: https://doi.org/10.1007/s10815-012-9875-y

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