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Recombinant luteinizing hormone supplementation to recombinant follicle-stimulation hormone during induced ovarian stimulation in the GnRH-agonist protocol: A meta-analysis

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Abstract

Purpose: to compare the efficacy of recombinant LH supplementation for controlled ovarian stimulation in recombinant FSH and GnRH-agonist protocol.

Methods: Search strategies included on-line surveys of databases. The fixed effects model was used for odds ratio and effect size (weighted mean difference). Four trials fulfilled the inclusion criteria.

Results: a fewer days of stimulation (p<0.0001), a fewer total amount of r-FSH administered (p<0.0001) and a higher serum estradiol levels on the day of hCG administration (p<0.0001) were observed for the r-LH supplementation protocol. However, differences were not observed in number of oocyte retrieved, number of mature oocytes, clinical pregnancy per oocyte retrieval, implantation and miscarriage rates.

Conclusions: more randomized controlled trials are necessary before evidence-based recommendations regarding exogenous LH supplementation in ovarian stimulation protocols with FSH and GnRH-agonist for assisted reproduction treatment can be provided.

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Authors and Affiliations

  1. Center for Human Reproduction Prof. Franco Junior, Ribeirão Preto, SP, Brazil

    João Batista A. Oliveira, Ana Lucia Mauri, Claudia G. Petersen, João Cornicelli, Ricardo L. R. Baruffi & José G. Franco Jr

  2. Department of Gynecology and Obstetrics, Faculty of Medicine of Botucatu, UNESP, Botucatu, SP, Brazil

    Ana Lucia Mauri, Claudia G. Petersen & Anice M. C. Martins

  3. Faculty of Medicine of Santo Amaro University, São Paulo, SP, Brazil

    Mario Cavanha

  4. Department of Gynecology and Obstetrics, Faculty of Medicine of Botucatu, UNESP, Botucatu, SP, Brazil

    Anagloria Pontes & José G. Franco Jr

  5. João Fiusa, 689-CEP 14025-310, Ribeirão Preto, SP, Brazil

    José G. Franco Jr

Authors
  1. João Batista A. Oliveira
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  2. Ana Lucia Mauri
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  4. Anice M. C. Martins
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  5. João Cornicelli
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  6. Mario Cavanha
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  7. Anagloria Pontes
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  8. Ricardo L. R. Baruffi
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  9. José G. Franco Jr
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Correspondence to José G. Franco Jr.

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Oliveira, J.B.A., Mauri, A.L., Petersen, C.G. et al. Recombinant luteinizing hormone supplementation to recombinant follicle-stimulation hormone during induced ovarian stimulation in the GnRH-agonist protocol: A meta-analysis. J Assist Reprod Genet 24, 67–75 (2007). https://doi.org/10.1007/s10815-006-9095-4

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  • DOI: https://doi.org/10.1007/s10815-006-9095-4

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