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Detection of Methamphetamine and Morphine in Urine and Saliva Using Excitation–Emission Matrix Fluorescence and a Second-Order Calibration Algorithm

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Journal of Applied Spectroscopy Aims and scope

A new method was developed to determine the methamphetamine and morphine concentrations in urine and saliva based on excitation–emission matrix fluorescence coupled to a second-order calibration algorithm. In the case of single-drug abuse, the results showed that the average recoveries of methamphetamine and morphine were 95.3 and 96.7% in urine samples, respectively, and 98.1 and 106.2% in saliva samples, respectively. The relative errors were all below 5%. The simultaneous determination of methamphetamine and morphine in urine using two second-order algorithms was also investigated. Satisfactory results were obtained with a self-weighted alternating trilinear decomposition algorithm. The root-mean-square errors of the predictions were 0.540 and 0.0382 μg/mL for methamphetamine and morphine, respectively. The limits of detection of the proposed methods were very low and sufficient for studying methamphetamine and morphine in urine.

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Authors and Affiliations

  1. Department of Forensic Toxicological Analysis, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China

    B. Y. Xu, Y. Ye & L. C. Liao

  2. Sichuan Provincial Department of Public Security, Chengdu, 610041, China

    B. Y. Xu

Authors
  1. B. Y. Xu
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  2. Y. Ye
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  3. L. C. Liao
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Correspondence to L. C. Liao.

Additional information

Published in Zhurnal Prikladnoi Spektroskopii, Vol. 83, No. 3, pp. 390–397, May–June, 2016.

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Xu, B.Y., Ye, Y. & Liao, L.C. Detection of Methamphetamine and Morphine in Urine and Saliva Using Excitation–Emission Matrix Fluorescence and a Second-Order Calibration Algorithm. J Appl Spectrosc 83, 383–391 (2016). https://doi.org/10.1007/s10812-016-0299-9

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  • DOI: https://doi.org/10.1007/s10812-016-0299-9

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