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Neuroprotective activities of natural products from marine macroalgae during 1999–2015

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Abstract

This review focuses on macroalgae-derived compounds with neuroprotective activity that may provide lead compounds for the prevention and treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Coverage is provided from 1999 to 2015. A total of 99 pure compounds have been reported. The main in vitro bioactivities of these compounds include inhibition of beta amyloid protein (Aβ), inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), reduction in oxidative stress, anti-inflammatory activity, inhibition of kinases, enhancement of neurite outgrowth and the reduction in dopaminergic neurotoxicity. The majority of these bioactive compounds are derived from Phaeophyceae (57.6 %), followed by Rhodophyta (28.3 %) and Chlorophyta (14.1 %). This review presents valuable knowledge on macroalgae-derived compounds and their known pathways of neuroprotection to further explore the potential of these compounds in preventing and treating neurodegenerative diseases.

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Acknowledgments

Mousa Alghazwi is supported by a scholarship from The Ministry of Higher Education in Saudi Arabia. The research project is supported by Flinders Centre for Marine Bioproducts Development, Flinders University. WPG is supported by NHMRC Fellowship (535014) and Flinders Fellowship and the Flinders-CSU seeding grant.

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Authors and Affiliations

  1. Flinders Centre for Marine Bioproducts Development (CMBD), Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia

    Mousa Alghazwi, Yen Qi Kan & Wei Zhang

  2. Department of Medical Biotechnology, School of Medicine, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia

    Mousa Alghazwi, Yen Qi Kan & Wei Zhang

  3. Ministry of Higher education in Saudi Arabia, King Faisal Hospital Street, Riyadh, 11153, Saudi Arabia

    Mousa Alghazwi

  4. Department of Physiology, School of Medicine, Flinders Medical Centre, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia

    Wei Ping Gai

  5. School of Chemistry and Molecular Biosciences, Faculty of Science, The University of Queensland, Queensland, Australia

    Mary J. Garson

  6. Discipline of Pharmacology, School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, South Australia, Australia

    Scott Smid

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  1. Mousa Alghazwi
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  2. Yen Qi Kan
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  3. Wei Zhang
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  4. Wei Ping Gai
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  5. Mary J. Garson
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Correspondence to Mousa Alghazwi or Wei Zhang.

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Alghazwi, M., Kan, Y.Q., Zhang, W. et al. Neuroprotective activities of natural products from marine macroalgae during 1999–2015. J Appl Phycol 28, 3599–3616 (2016). https://doi.org/10.1007/s10811-016-0908-2

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  • DOI: https://doi.org/10.1007/s10811-016-0908-2

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