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Facile synthesis of Co3O4/C porous polyhedrons for voltammetric determination of quercetin in human serum and urine

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Abstract

Due to the highly porous structure, metal organic framework (MOF)-derived materials are extensively applied in the field of electroanalysis. In this experiment, an effective electrochemical sensing based on Co3O4/C-derived ZIF-67 MOF had been constructed for ultrasensitive determination of quercetin at trace level. The resultant Co3O4/C porous polyhedron of morphology and nanostructure were carefully examined using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Brunauer–Emmett–Teller (BET) techniques. Differential pulse anodic stripping voltammetry (DPV) method was adopted to analyze quercetin under the optimized conditions. The DPV response of Co3O4/C film-coated glass carbon electrode (Co3O4/C/GCE) for quercetin determination was achieved a long linearity ranging from 0.5 to 30 µM, achieving high sensitivity about 1.830 × 10− 6 A cm− 2 µM− 1, and the detection limit was calculated to be 0.022 µM (S/N = 3). Besides, the fabricated Co3O4/C/GCE displayed excellent selectivity, desirable repeatability, and good reproducibility. More importantly, the proposed sensor exhibited satisfactory recovery ranges and accuracy for the determination of trace quercetin in human urine and serum samples, which will make it as an alternative advantageous choice for practical on-site determination.

Graphical abstract

The porous Co3O4/C polyhedron derived by ZIF-67 MOF was successfully synthesized. The as-synthesized material was employed to prepare chemically modified electrode for ultrasensitive determination of quercetin. Then the Co3O4/C-modified glass carbon electrode is displayed good sensitivity and accuracy toward quercetin in urine and serum samples.

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Acknowledgements

This work was supported by the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) (CMEMR2019-B10) and Light of Bagui of Academic Research and Studies Program in 2021 (Gui Zu Tong Zi, Document No. 64 of 2021).

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  1. Yi Zhang and Liwen Zhang have contributed equally to this work.

Authors and Affiliations

  1. School of Medicine, Guangxi University of Science and Technology, Guangxi, 545006, Liuzhou, People’s Republic of China

    Yi Zhang, Tingcui Gong & Jun Feng

  2. Guangxi Key Laboratory of Green Processing of Sugar Resources, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Guangxi, 545006, Liuzhou, People’s Republic of China

    Liwen Zhang, Tianhao Li, Xuenuan Li, Jun Feng, Tingfan Tang & Hao Cheng

  3. Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Guangxi, 530004, Nanning, People’s Republic of China

    Hao Cheng

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  1. Yi Zhang
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Zhang, Y., Zhang, L., Gong, T. et al. Facile synthesis of Co3O4/C porous polyhedrons for voltammetric determination of quercetin in human serum and urine. J Appl Electrochem 52, 1607–1616 (2022). https://doi.org/10.1007/s10800-022-01731-9

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