Abstract
Ultrasonic velocities and densities of the drug Parvon-spas in binary mixtures of water with methanol (MeOH), ethanol (EtOH), and propan-1-ol (1-PrOH) have been measured over the complete solvent composition range at 10 mol% intervals at 25°C. Various acoustic parameters such as the acoustic impedance (Z), adiabatic compressibility (β), intermolecular free length (L f ), relative association (R.A.), molar volume (V m ), and molar sound velocity (R m ) have been calculated. In addition, excess functions, i.e., excess adiabatic compressibility (βE), excess intermolecular free length (L E f ), excess molar volume (VE), excess ultrasonic velocity (UE), and excess acoustic impedance (ZE) for these three solvent mixtures in the absence and presence of the drug have been calculated. A different behavior of these parameters in these alcohol systems has been discussed in terms of the length of the alcohol molecule, the molecular volume, as well as inter/intramolecular interactions of these molecules.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chauhan S., Syal V.K., and Chauhan M.S., Indian J. Pure Appl. Phys. 32:186 (1994); 33:92 (1995).
V.K. Syal G. Lal P. Bisht S. Chauhan (1995) J . Mol. Liquids 63 317 Occurrence Handle10.1016/0167-7322(94)00795-X
A. Korol Kovas (1988) Essentials of Medicinal Chemistry. Chap. 3 EditionNumber2 Wiley New York
J.B. Stenlake (1975) Foundations of Molecular Pharmacology Athlone Press London
M. Rowland T.N. Tozer (1989) Clinical Pharmokinetics, Concepts and Applications Lea and Febiger Malvern, Pennsylvania
M. Gibaldi (1991) Biopharmaceuits and Clinical Pharmokinetics EditionNumber4 Lea and Febiger, Malvern Pennsylvania
M.S. Bakshi G. Kumar (1997) J. Chem. Eng. Data 42 298 Occurrence Handle10.1021/je960300p
A. Pal G. Dass (2001) Zeitschrift fur Physikalische chemie 215 943
P. Venkatesu M.V. Prabhakar Rao (1999) Ind. J. Pure Appl. Phys. 37 59
R.C. Weast (1988-1989) CRC Handbook of Chemistry and Physics EditionNumber69 CRC Press Inc Boca Raton, Florida
J.D. Pandey Kumar Ashok (1994) J. Pure Appl. Ultrasonics 16 63
Kar Ashotosh (1993) Medicinal Chemistry Wiley Eastern Ltd. New Delhi
S.K. Maity A.K. Chattopadhyay S.C. Lahari (1980) Electro Chimica Acta 25 148
V.K. Syal R. Gautam S. Chauhan (1998) Indian J. Pure Appl. Phys. 36 108
V.K. Syal R. Gautam S. Chauhan (1998) Ultrasonics 36 619 Occurrence Handle10.1016/S0041-624X(97)00104-2
V. Rajendran (1995) J. Pure Appl. Ultrasonics 17 65
F. Franks D.J.G Ives (1966) Quart. Rev. 20 1 Occurrence Handle10.1039/qr9662000001
B. Eyring J.F. Kincaid (1938) J. Chem. Phys. 6 620 Occurrence Handle10.1063/1.1750134
M.S. Chauhan K.C. Sharma S. Gupta M. Sharma S. Chauhan (1995) Acoustic Lett. 18 233 Occurrence Handle10.1016/0375-9601(95)00535-B
V.K. Syal B.S. Patial S. Chauhan (1999) Indian J. Pure Appl. Phys. 37 366
M.S. Chauhan K.C. Sharma S. Gupta (1995) Acoustic Lett. 18 233 Occurrence Handle10.1016/0375-9601(95)00535-B
V.K. Syal M.S. Chauhan B.K. Chandra S. Chauhan (1996) J. Pure Appl. Ultrasonics 18 104
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Syal, V.K., Thakur, S.K., Chauhan, S. et al. Ultrasonic Velocity Studies of Drug Parvon-spas in Mixed Alcohol–Water Solvent Systems at 25°C. Int J Thermophys 26, 807–826 (2005). https://doi.org/10.1007/s10765-005-5579-1
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10765-005-5579-1