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Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis

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Abstract

IL4 -589C/T polymorphism has been implicated in susceptibility to pediatric asthma risk. Several studies investigated the association of this polymorphism with pediatric asthma in different populations. However, the results were contradictory. A meta-analysis was conducted to assess the association between IL4 -589C/T polymorphism and pediatric asthma risk. Databases including Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wangfang were searched to find relevant studies. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. A significant association was found between IL4 -589C/T polymorphism and pediatric asthma risk (OR = 1.53, 95% CI 1.27–1.85). In the subgroup analyses by ethnicity, the significant association was found among Caucasians (OR = 1.70, 95 % CI 1.38–2.09) and Asians (OR = 1.58, 95 % CI 1.23–2.04). Our results suggested that IL4 -589C/T polymorphism conferred a risk factor of pediatric asthma.

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Authors and Affiliations

  1. Pediatrics Department, The First Affiliated Hospital of Zhengzhou University, The Construction East Road No. 1 in Erqi District, Zhengzhou, 450052, Henan, China

    Suqin Zhang, Yuqin Li & Yufeng Liu

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  1. Suqin Zhang
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  2. Yuqin Li
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  3. Yufeng Liu
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Correspondence to Yufeng Liu.

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Zhang, S., Li, Y. & Liu, Y. Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis. Inflammation 38, 1207–1212 (2015). https://doi.org/10.1007/s10753-014-0086-9

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  • DOI: https://doi.org/10.1007/s10753-014-0086-9

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