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Serum Soluble Triggering Receptor on Myeloid Cells-1 (sTREM-1) is Elevated in Systemic Lupus Erythematosus but does not Distinguish Between Lupus Alone and Concurrent Infection

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Abstract

We sought to determine serum triggering receptor expressed on myeloid cell-1 (sTREM-1) level in a cohort of patients with systemic lupus erythematosus (SLE). Serum sTREM-1 level of 98 patients with SLE and 49 healthy controls was assayed by ELISA. Serum sTREM-1 level was significantly elevated in a cohort of 78 unselected consecutively recruited patients with SLE (mean 1.1 ± 2.8 ρg/ml, median 0.02 ρg/ml) compared to that of the controls (mean 0.11 ± 0.3 ρg/ml, median 0 ρg/ml; p < 0.0001). We also determined serum sTREM-1 level of 20 SLE patients with a concurrent infection (mean 0.6 ± 1.1 ρg/ml, median 0.12 ρg/ml) and found it not statistically significant compared with that of the patients without infection. Serum sTREM-1 level did not correlate with SLE disease activity. Our finding of elevated serum sTREM-1 level suggests an increased shedding of TREM-1 in SLE and a possible novel pathway of innate immune response in autoimmunity.

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Authors and Affiliations

  1. Beilinson Hospital, Rabin Medical Center, Tel Aviv University, Petach Tikva, Israel

    Yair Molad, Tania Kaptzan, Assaf Monselise & Michal Shalita-Chesner

  2. Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Beilinson Campus, Petach Tikva, 49100, Israel

    Yair Molad & Elisheva Pokroy-Shapira

  3. Laboratory of Clinical Immunology, Beilinson Hospital, Rabin Medical Center, Petach Tikva, 49100, Israel

    Yehudit Monselise

  4. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Yair Molad

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  1. Yair Molad
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Correspondence to Yair Molad.

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Molad, Y., Pokroy-Shapira, E., Kaptzan, T. et al. Serum Soluble Triggering Receptor on Myeloid Cells-1 (sTREM-1) is Elevated in Systemic Lupus Erythematosus but does not Distinguish Between Lupus Alone and Concurrent Infection. Inflammation 36, 1519–1524 (2013). https://doi.org/10.1007/s10753-013-9694-z

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  • DOI: https://doi.org/10.1007/s10753-013-9694-z

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