Abstract
Pentraxin 3 is an acute phase marker that belongs to the same protein family as C-reactive protein (CRP). The aim of this study was to compare the acute phase reactions of pentraxin 3 and CRP in humans. High sensitivity CRP and pentraxin 3 were analyzed in blood samples from orthopedic surgery (n = 29) and coronary bypass patients (n = 21). The samples were collected prior to surgery and 4 and 30 days after surgery, respectively. Both CRP and pentraxin 3 were significantly increased at day 4. Median pentraxin 3 values increased from 4,021 to 7,459 pg/mL in the orthopedic group and from 4,637 pg/mL to 10,419 pg/mL in the coronary bypass group while CRP increased from 6.3 mg/L to 151.6 mg/L and from 5.7 mg/L to 176.3 mg/L in the same groups. Pentraxin 3 shows a much smaller increment in humans in comparison with CRP.
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Acknowledgements
This study was financially supported by the Uppsala University Hospital Research Fund and Uppsala Berzelii Center. We thank Christine Leo Swenne and Lena Gunningberg for organizing the blood sample collection.
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Åkerfeldt, T., Larsson, A. Pentraxin 3 Increase is Much Less Pronounced Than C-Reactive Protein Increase After Surgical Procedures. Inflammation 34, 367–370 (2011). https://doi.org/10.1007/s10753-010-9243-y
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DOI: https://doi.org/10.1007/s10753-010-9243-y