Abstract
Growing melanomas invade the subcutaneous tissues. We have compared the size of tumors implanted in the subcutaneous cavities of C57BL/6 mice where inflammatory reactions were induced before the injection of 5×105 melanoma cells (B16F10 cell line). Granulocytic inflammation of the subcutaneous cavities resulted in a significant decrease in the growth of the implanted melanomas, whereas monocytic inflammation had no effect on tumor growth. We conclude that granulocytes, but not monocytes/macrophages, have anti-tumor action on melanoma that invade the subcutaneous tissues.
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Costa, M.M., Águas, A.P. Inflammatory Granulocytes Decrease Subcutaneous Growth of Melanoma in Mice. Inflammation 28, 355–357 (2004). https://doi.org/10.1007/s10753-004-6646-7
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DOI: https://doi.org/10.1007/s10753-004-6646-7