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Mechanisms for heart failure in systemic right ventricle

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Abstract

There are two predominant scenarios where the right ventricle acts as the systemic ventricle, namely congenitally corrected transposition of the great arteries (CC-TGA) and patients with D-transposition of the great arteries (D-TGA) who have undergone an atrial switch operation. There is evidence that having a right ventricle in the systemic position predisposes to the development of heart failure. In this review, we aim to explore the proposed mechanisms and pathophysiology for heart failure in patients with a systemic right ventricle in these two subsets of patients.

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Authors and Affiliations

  1. Division of Cardiology, University of Pennsylvania, Philadelphia, PA, USA

    Lauren Andrade & Yuli Kim

  2. Division of Cardiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Lauren Andrade & Yuli Kim

  3. Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA

    Matthew Carazo

  4. Department of Cardiology, Boston Children’s Hospital, Boston, MA, USA

    Fred Wu

  5. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Fred Wu

  6. Royal Melbourne Hospital, Melbourne, VIC, Australia

    William Wilson

  7. University of Melbourne, Melbourne, VIC, Australia

    William Wilson

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Andrade, L., Carazo, M., Wu, F. et al. Mechanisms for heart failure in systemic right ventricle. Heart Fail Rev 25, 599–607 (2020). https://doi.org/10.1007/s10741-019-09902-1

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