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Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

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Abstract

It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.

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Abbreviations

A-LAP:

Adipocyte-derived leucine aminopeptidase

Ang:

Angiotensin

APA:

Aminopeptidase A

APN:

Aminopeptidase N

BP:

Blood pressure

GLUT:

Glucose transporter

P-LAP:

Placental leucine aminopeptidase

RAS:

Renin-angiotensin system

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Authors and Affiliations

  1. Laboratory of Cellular Biochemistry, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan

    Masafumi Tsujimoto, Yoshikuni Goto, Masato Maruyama & Akira Hattori

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  1. Masafumi Tsujimoto
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  2. Yoshikuni Goto
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  3. Masato Maruyama
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  4. Akira Hattori
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Correspondence to Masafumi Tsujimoto.

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Tsujimoto, M., Goto, Y., Maruyama, M. et al. Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure. Heart Fail Rev 13, 285–291 (2008). https://doi.org/10.1007/s10741-007-9064-8

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