Abstract
This collection of papers covers developments in a rapidly growing area, sarcomeric proteins in hypertrophied and failing myocardium. Advances in our understanding of the biochemistry and biophysics of crossbridge cycling, contributions of thick versus thin filament and the emerging role of titin, the importance and mechanisms of mutations in causing disease, and an integrated understanding of the consequences of sarcomeric protein alterations at the organ level are discussed.
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References
Alpert NR, Gordon MS. Myofibrillar adenosine triphosphatase activity in congestive heart failure. Am J Physiol 1962;202:940–946.
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LeWinter, M.M., VanBuren, P. Sarcomeric Proteins in Hypertrophied and Failing Myocardium: An Overview. Heart Fail Rev 10, 173–174 (2005). https://doi.org/10.1007/s10741-005-5247-3
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DOI: https://doi.org/10.1007/s10741-005-5247-3