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The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

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Abstract

The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.

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Authors and Affiliations

  1. Department of Pathology and Comprehensive Cancer Center, University of Michigan, 3510C MSRB1, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109, USA

    Michael Zeidler & Celina G. Kleer

Authors
  1. Michael Zeidler
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  2. Celina G. Kleer
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Corresponding author

Correspondence to Celina G. Kleer.

Additional information

Grant support: This work was supported in part by National Cancer Institute Grants K08CA090876 (CGK) and R01CA107469 (CGK), and Department of Defense grant DAMD17-01-1-490 (CGK).

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Zeidler, M., Kleer, C.G. The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer. J Mol Hist 37, 219–223 (2006). https://doi.org/10.1007/s10735-006-9042-9

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  • DOI: https://doi.org/10.1007/s10735-006-9042-9

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