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Nucleotide sequence ofbup, an upstream gene in thebmi-1 proviral insertion locus

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Abstract

The ability of Moloney murine leukemia virus to accelerate lymphomagenesis in Eμ-myc transgenic mice is frequently associated with proviral integration within a locus denotedbmi-1. This locus contains not only thebmi-1 gene implicated as a collaborator withmyc in lymphomagenesis but also just upstream an unknown gene denotedbup. The nucleotide sequence reported here forbup cDNA and flanking genomic sequences reveals that this widely expressed gene comprises at least 7 exons and potentially encodes a polypeptide of 195 amino acid residues. Computer searches with this polypeptide sequence revealed no close homolog in the databases, nor any conserved motifs, and it is unrelated to the product of themel-13 gene, which lies just upstream from thebmi-1 homologmel-18.

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References

  1. van Lohuizen M & Berns A (1990) Biochim. Biophys. Acta. 1032: 213–235

    Google Scholar 

  2. Peters G (1990) Cell Growth & Diff. 1: 503–510

    Google Scholar 

  3. van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Rudaszkiewcz T & Berns A (1989) Cell 56: 673–682

    Google Scholar 

  4. Haupt Y, Alexander WS, Barri G, Klinken SP & Adams JM (1991) Cell 65: 753–763

    Google Scholar 

  5. van Lohuizen MP, Verbeek S, Scheijen B, Weintjenz E, van der Gulden H & Berns A (1991) Cell 65: 737–752

    Google Scholar 

  6. Haupt Y, Harris AW & Adams JM (1992) Oncogene 7: 981–986

    Google Scholar 

  7. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD & Brinster RL (1985) Nature 318: 533–538

    Google Scholar 

  8. Kozak M (1986) Cell 44: 283–292

    Google Scholar 

  9. Pearson WR & Lipman DJ (1988) Proc. Natl. Acad. Sci. USA 85: 2444–2448

    Google Scholar 

  10. Goebl G (1990) Cell 66: 623

    Google Scholar 

  11. Tagawa M, Sakamoto T, Shigemoto K, Matsubara H, Tamura Y, Ito T, Nakamura I, Okitsu A, Imai K & Taniguchi M (1990) J. Biol. Chem. 265: 20021–20026

    Google Scholar 

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, PO Box Royal Melbourne Hospital, 3050, Victoria, Australia

    Y. Haupt, G. Barri & J. M. Adams

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  1. Y. Haupt
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  2. G. Barri
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  3. J. M. Adams
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Haupt, Y., Barri, G. & Adams, J.M. Nucleotide sequence ofbup, an upstream gene in thebmi-1 proviral insertion locus. Mol Biol Rep 17, 17–20 (1993). https://doi.org/10.1007/BF01006395

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  • DOI: https://doi.org/10.1007/BF01006395

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