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Space-time Clustering Analyses of Testicular Cancer Amongst 15–24-year-olds in Northern England

  • Cancer
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Abstract

There has been speculation that environmental exposures may be involved in the aetiology of testicular cancer in adolescent boys and young men. Indirect evidence for this hypothesis would be provided by the finding of space-time clustering. To examine this we have looked for evidence of space-time clustering using data from a population-based cancer registry from Northern England. All cases of testicular cancer diagnosed in males aged 15–24 years during the period 1968–2002 were included in the study. Tests for space-time interactions between cases were applied with fixed thresholds of close in space and close in time. Addresses at birth and diagnosis were used in the analyses. To adjust for the effect of varying population density tests were repeated replacing fixed geographical distances with nearest neighbour thresholds. A total of 257 cases of testicular cancer were identified for analysis. Overall there was no evidence for space-time clustering. However, there was statistically significant space-time clustering for 15–19-year-old based on time of birth and place of diagnosis (p<0.001). The very limited finding of space-time clustering may provide tentative evidence for an environmental, or infectious component to aetiology. However, it may well be a chance finding. A larger study based on national data is required.

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References

  1. M Shabbir RJ Morgan (2004) ArticleTitleTesticular cancer J R Soc Health 124 217–218 Occurrence Handle15493780

    PubMed  Google Scholar 

  2. AJ Swerdlow BL Stavola ParticleDe MA Swanwick P Mangtani NE Machonachie (1999) ArticleTitleRisk factors for testicular cancer: a case-control study in twins Br J Cancer 80 1098–1102 Occurrence Handle10.1038/sj.bjc.6690470 Occurrence Handle1:STN:280:DyaK1M3ovV2luw%3D%3D Occurrence Handle10362123

    Article  CAS  PubMed  Google Scholar 

  3. F Bray R Sankila J Ferlay DM Parkin (2002) ArticleTitleEstimates of cancer incidence and mortality in Europe in 1995 Eur J Cancer 38 99–166 Occurrence Handle10.1016/S0959-8049(01)00350-1 Occurrence Handle1:STN:280:DC%2BD38%2Fgt1yitw%3D%3D Occurrence Handle11750846

    Article  CAS  PubMed  Google Scholar 

  4. MB Toledano L Jarup N Best J Wakefield P Elliott (2001) ArticleTitleSpatial variation and temporal trends of testicular cancer in Great Britain Br J Cancer 84 1482–1487 Occurrence Handle10.1054/bjoc.2001.1739 Occurrence Handle1:STN:280:DC%2BD3MzhtFGmsQ%3D%3D Occurrence Handle11384098

    Article  CAS  PubMed  Google Scholar 

  5. DA Power RS Brown CS Brock HA Payne A Majeed P Babb (2001) ArticleTitleTrends in testicular carcinoma in England and Wales, 1971–99 BJU Int 87 361–365 Occurrence Handle10.1046/j.1464-410x.2001.00078.x Occurrence Handle1:STN:280:DC%2BD3M3islymug%3D%3D Occurrence Handle11251531

    Article  CAS  PubMed  Google Scholar 

  6. M Cuninkova D Ondrus I Plesko J Mat’oska (2001) ArticleTitleEpidemiology of testicular tumors in Slovakia (1993–1997): preliminary report Int Urol Nephrol 32 669–675 Occurrence Handle1:STN:280:DC%2BD383lt1GjsQ%3D%3D Occurrence Handle11989562

    CAS  PubMed  Google Scholar 

  7. KA McGlynn SS Devesa AJ Sigurdson LM Brown L Tsao RE Tarone (2003) ArticleTitleTrends in the incidence of testicular germ cell tumors in the United States Cancer 97 63–70 Occurrence Handle10.1002/cncr.11054 Occurrence Handle12491506

    Article  PubMed  Google Scholar 

  8. HK Weir LD Marrett V Moravan (1999) ArticleTitleTrends in the incidence of testicular germ cell cancer in Ontario by histologic subgroup, 1964–1996 CMAJ 160 201–205 Occurrence Handle1:STN:280:DyaK1M7js1GqsA%3D%3D Occurrence Handle9951441

    CAS  PubMed  Google Scholar 

  9. S Liu R Semenciw C Waters SW Wen LS Mery Y Mao (2000) ArticleTitleClues to the aetiological heterogeneity of testicular seminomas and non-seminomas: time trends and age-period-cohort effects Int J Epidemiol 29 826–831 Occurrence Handle1:STN:280:DC%2BD3M%2FltlWhsg%3D%3D Occurrence Handle11034964

    CAS  PubMed  Google Scholar 

  10. H Moller (2001) ArticleTitleTrends in incidence of testicular cancer and prostate cancer in Denmark Hum Reprod 16 1007–1011 Occurrence Handle10.1093/humrep/16.5.1007 Occurrence Handle1:STN:280:DC%2BD3MvitlCmug%3D%3D Occurrence Handle11331652

    Article  CAS  PubMed  Google Scholar 

  11. L Richiardi R Bellocco HO Adami et al. (2004) ArticleTitleTesticular cancer incidence in eight northern European countries: secular and recent trends Cancer Epidemiol Biomarkers Prev 13 2157–2166 Occurrence Handle15598775

    PubMed  Google Scholar 

  12. E Huyghe T Matsuda P Thonneau (2003) ArticleTitleIncreasing incidence of testicular cancer worldwide: a review J Urol 170 5–11 Occurrence Handle10.1097/01.ju.0000053866.68623.da Occurrence Handle12796635

    Article  PubMed  Google Scholar 

  13. T Gudbjartsson K Magnusson J Bergthorsson et al. (2003) ArticleTitleA population-based analysis of increased incidence and improved survival of testicular cancer patients in Iceland Scand J Urol Nephrol 37 292–298 Occurrence Handle12944186

    PubMed  Google Scholar 

  14. RM Sharpe (2003) ArticleTitleThe ‘oestrogen hypothesis’ – where do we stand now? Int J Androl 26 2–15 Occurrence Handle1:CAS:528:DC%2BD3sXhsFais74%3D Occurrence Handle12534932

    CAS  PubMed  Google Scholar 

  15. CG Ohlson L Hardell (2000) ArticleTitleTesticular cancer and occupational exposures with a focus on xenoestrogens in polyvinyl chloride plastics Chemosphere 40 1277–1282 Occurrence Handle10.1016/S0045-6535(99)00380-X Occurrence Handle1:CAS:528:DC%2BD3cXhslSmtbY%3D Occurrence Handle10739073

    Article  CAS  PubMed  Google Scholar 

  16. HK Weir LD Marrett N Kreiger GA Darlington L Sugar (2000) ArticleTitlePre-natal and peri-natal exposures and risk of testicular germ-cell cancer Int J Cancer 87 438–443 Occurrence Handle10.1002/1097-0215(20000801)87:3<438::AID-IJC20>3.0.CO;2-1 Occurrence Handle1:STN:280:DC%2BD3cvlvVamsg%3D%3D Occurrence Handle10897052

    Article  CAS  PubMed  Google Scholar 

  17. PB English DE Goldberg C Wolff D Smith (2003) ArticleTitleParental and birth characteristics in relation to testicular cancer risk among males born between 1960 and 1995 in California (United States) Cancer Cause Control 14 815–825

    Google Scholar 

  18. L Hardell B Bavel ParticleVan G Lindstram et al. (2003) ArticleTitleIncreased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer Environ Health Perspect 111 930–934 Occurrence Handle1:CAS:528:DC%2BD3sXltlKitL0%3D Occurrence Handle12782494

    CAS  PubMed  Google Scholar 

  19. MU Hentrich NG Brack P Schmid T Schuster C Clemm RC Hartenstein (1996) ArticleTitleTesticular germ cell tumors in patients with human immunodeficiency virus infection Cancer 77 2109–2116 Occurrence Handle10.1002/(SICI)1097-0142(19960515)77:10<2109::AID-CNCR22>3.0.CO;2-Y Occurrence Handle1:STN:280:BymB3cngtlQ%3D Occurrence Handle8640678

    Article  CAS  PubMed  Google Scholar 

  20. T Powles M Bower G Daugaard et al. (2003) ArticleTitleMulticenter study of human immunodeficiency virus-related germ cell tumors J Clin Oncol 21 1922–1927 Occurrence Handle10.1200/JCO.2003.09.107 Occurrence Handle1:STN:280:DC%2BD3s3itFKntw%3D%3D Occurrence Handle12743144

    Article  CAS  PubMed  Google Scholar 

  21. LM Brown LM Pottern RN Hoover (1987) ArticleTitleTesticular cancer in young men: the search for causes of the epidemic increase in the United States J Epidemiol Comm Health 41 349–354 Occurrence Handle1:STN:280:BieA3s3hvFE%3D

    CAS  Google Scholar 

  22. O Akre L Lipworth S Tretli et al. (1999) ArticleTitleEpstein-Barr virus and cytomegalovirus in relation to testicular cancer risk: a nested case-control study Int J Cancer 82 1–5 Occurrence Handle10.1002/(SICI)1097-0215(19990702)82:1<1::AID-IJC1>3.0.CO;2-L Occurrence Handle1:STN:280:DyaK1M3oslGmtA%3D%3D Occurrence Handle10360811

    Article  CAS  PubMed  Google Scholar 

  23. C Carroll-Pankhurst EA Engels HD Strickler JJ Goedert J Wagner EA Mortimer SuffixJr (2001) ArticleTitleThirty-five year mortality following receipt of SV40-contaminated polio vaccine during the neonatal period Br J Cancer 85 1295–1297 Occurrence Handle10.1054/bjoc.2001.2065 Occurrence Handle1:STN:280:DC%2BD3MnnsVylug%3D%3D Occurrence Handle11720463

    Article  CAS  PubMed  Google Scholar 

  24. E Compton (1972) Local Government Boundary Commission Reports HMSO London

    Google Scholar 

  25. SJ Cotterill L Parker AJ Malcolm M Reid L More AW Craft (2000) ArticleTitleIncidence and survival for cancer in children and young adults in the North of England, 1968–1995: A report from the Northern Region Young Persons’ Malignant Disease Registry Br J Cancer 83 397–403 Occurrence Handle10.1054/bjoc.2000.1313 Occurrence Handle1:STN:280:DC%2BD3cznt1ahtA%3D%3D Occurrence Handle10917558

    Article  CAS  PubMed  Google Scholar 

  26. AW Craft L Parker S Openshaw et al. (1993) ArticleTitleCancer in young people in the North of England, 1968–85: Analysis by census wards J Epidemiol Comm Health 47 109–115 Occurrence Handle1:STN:280:ByyA3Mngt10%3D

    CAS  Google Scholar 

  27. DT Schneider G Calaminus S Koch et al. (2004) ArticleTitleEpidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols Paediatr Blood Cancer 42 169–175

    Google Scholar 

  28. JM Birch FE Alexander V Blair OB Eden GM Taylor RJQ McNally (2000) ArticleTitleSpace-time clustering patterns in childhood leukaemia support a role for infection Br J Cancer 82 1571–1576 Occurrence Handle1:STN:280:DC%2BD3c3kvVGruw%3D%3D Occurrence Handle10789727

    CAS  PubMed  Google Scholar 

  29. RJQ McNally DP Cairns OB Eden et al. (2002) ArticleTitleAn infectious aetiology for childhood brain tumours? Evidence from space-time clustering and seasonality analyses Br J Cancer 86 1070–1077 Occurrence Handle10.1038/sj.bjc.6600228 Occurrence Handle1:STN:280:DC%2BD383hs1Kgug%3D%3D Occurrence Handle11953851

    Article  CAS  PubMed  Google Scholar 

  30. RJQ McNally FE Alexander JM Birch (2002) ArticleTitleSpace-time clustering analyses of childhood acute lymphoblastic leukaemia by immunophenotype Br J Cancer 87 513–515 Occurrence Handle10.1038/sj.bjc.6600498 Occurrence Handle1:STN:280:DC%2BD38vjtFyqtg%3D%3D Occurrence Handle12189547

    Article  CAS  PubMed  Google Scholar 

  31. RJQ McNally AM Kelsey OB Eden FE Alexander DP Cairns JM Birch (2003) ArticleTitleSpace-time clustering patterns in childhood solid tumours other than central nervous system tumours Int J Cancer 103 253–258 Occurrence Handle10.1002/ijc.10812 Occurrence Handle1:CAS:528:DC%2BD38XpslWmu7c%3D Occurrence Handle12455041

    Article  CAS  PubMed  Google Scholar 

  32. RJQ McNally FE Alexander OB Eden JM Birch (2004) ArticleTitleLittle or no space-time clustering found amongst cases of childhood lymphoma in North West England Eur J Cancer 40 585–589 Occurrence Handle1:STN:280:DC%2BD2c%2FntlKgtA%3D%3D Occurrence Handle14962727

    CAS  PubMed  Google Scholar 

  33. RJQ McNally TOB Eden FE Alexander AM Kelsey JM Birch (2005) ArticleTitleIs there a common aetiology for certain childhood cancers? Results of cross-space-time clustering analyses Eur J Cancer 41 2911–2916 Occurrence Handle10.1016/j.ejca.2005.04.051 Occurrence Handle16243517

    Article  PubMed  Google Scholar 

  34. EG Knox (1964) ArticleTitleThe detection of space-time interactions Applied Stats 13 25–29

    Google Scholar 

  35. PJ Diggle AG Chetwynd R Haggkvist SE Morris (1995) ArticleTitleSecond-order analysis of space-time clustering Stat Methods Med Res 4 124–136 Occurrence Handle1:STN:280:BymD28fgt1A%3D Occurrence Handle7582201

    CAS  PubMed  Google Scholar 

  36. AG Knudson (1996) ArticleTitleHereditary cancer: two hits revisited J Cancer Res Clin Oncol 122 135–140 Occurrence Handle10.1007/BF01366952 Occurrence Handle1:STN:280:BymC1c%2Fks1c%3D Occurrence Handle8601560

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Clinical Medical Sciences (Child Health), University of Newcastle Upon Tyne, Newcastle upon Tyne, United Kingdom

    R. J. Q. McNally, M. S. Pearce & L. Parker

  2. School of Population and Health Sciences, University of Newcastle Upon Tyne, Newcastle upon Tyne, United Kingdom

    R. J. Q. McNally

  3. Sir James Spence Institute, Level 4, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, United Kingdom

    R. J. Q. McNally

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  1. R. J. Q. McNally
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Correspondence to R. J. Q. McNally.

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McNally, R.J.Q., Pearce, M.S. & Parker, L. Space-time Clustering Analyses of Testicular Cancer Amongst 15–24-year-olds in Northern England. Eur J Epidemiol 21, 139–144 (2006). https://doi.org/10.1007/s10654-005-5698-9

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