Abstract
Objective: To evaluate health impact of boron in drinking water. Methods: A regional scale geographical study in Northern France was conducted. Assessment of boron blood levels in a group of 180 healthy individuals and correlation with boron content in drinking water were followed by an assessment of health indicators such as birth rates, mortality rates, and sex ratios in zones of different boron content in drinking water. Results: After necessary adjustments, men living in municipalities with more than 0.30 mg/L of boron in drinking water had elevated but not significant boron blood levels compared with those living in municipalities with boron water levels of less than 0.30 mg/L (159.1 versus 123.0 ng/g; p > 0.05). The standardized birth ratio adjusted for the reference geographic zone and calendar time period was 1.07 and 1.28 in the low and high (>0.3 mg/L) boron content municipalities, respectively. The birth rate in municipalities with high boron content in drinking water was higher than that of the reference geographic zone and of the French general population (p < 10-4). The standardized mortality ratio adjusted for the reference geographic zone and calendar time period was 0.94 and 0.92 in the low and high boron content municipalities, respectively. The mortality rate in municipalities with high boron content in drinking water was less than that of the reference geographic zone and of the French general population (p < 10-3). No statistical difference was noted in the male–female sex ratios between the different municipality zones (p = 0.45). Conclusions: The results of this study do not support the idea of a deleterious effect of boron on human health, at the boron water level contents found in this specific region. In fact, there is a tendency toward a beneficial effect with low-dose environmental exposure (less than 1 mg/L of boron) in drinking water.
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References
Y Bai CD Hunt (1996) ArticleTitleAbsorption and distribution of boron in rats following a single oral administration of boron Proc North Dakota Acad Sci 50 53
Blin F, Bernard D, Pain JM et al. 1996 Aperçu des teneurs en Bore et en Nickel dans les eaux souterraines du bassin Artois-Picardie. TSM 10 (91 année), 680–685
L Butterwick N Oude ParticleDe K Raymond (1989) ArticleTitleSafety assessment of boron in aquatic and terrestrial environments Ecotoxicol Environ Saf 17 339–371 Occurrence Handle10.1016/0147-6513(89)90055-9
BD Culver PT Shen TH Taylor FA Lee CH Anton PL Strong (1994) ArticleTitleThe relationship of blood and urine boron to boron exposure in borax workers and the usefulness of urine boron as an exposure marker Environ Health Perspect 102 IssueIDSuppl 7 133–137
DH Garabrant L Bernstein JM Peters TJ Smith (1984) ArticleTitleRespiratory and eye irritation from boron oxide and boric acid dusts J Occup Med 26 584–586
DH Garabrant L Bernstein JM Peters TJ Smith (1985) ArticleTitleRespiratory effects of borax dust Br J Ind Med 42 831–837
JJ Heindel CJ Price EA Field et al. (1992) ArticleTitleDevelopmental toxicity of boric acid in mice and rats Fundam Appl Toxicol 18 266–277 Occurrence Handle10.1016/0272-0590(92)90055-M
G Huel F Derriennic P Lazar (1979) ArticleTitleProblèmes méthodologiques liés à la contiguité et à la taille des unités géographiques étudiées Rev Epidem et Santé Publ 27 520–522
G Huel JF Petiot P. Lazar (1986) ArticleTitleAlgorithm for the grouping of contiguous geographical zones Stat in Med 5 171–181
G Huel C Yazbeck D Burnel P Missy W Kloppmann (2004) ArticleTitleEnvironmental boron exposure and activity of delta-aminolevulinic acid dehydratase (ALA-D) in a newborn population Toxicol Sci 80 304–309 Occurrence Handle10.1093/toxsci/kfh165
CD Hunt (1989) ArticleTitleDietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick Biol Trace Elem Res 22 201–220 Occurrence Handle10.1007/BF02916650
JA Jansen J Anderson JS Schou (1984) ArticleTitleBoric acid single dose pharmacokinetics after intravenous administration to man Arch Toxicol 55 64–67 Occurrence Handle10.1007/BF00316588
WW Ku RE Chapin RF Moseman RE Brink KD Pierce KY Adams (1991) ArticleTitleTissue disposition of boron in Fischer rats Toxicol Appl Pharmacol 111 145–151 Occurrence Handle10.1016/0041-008X(91)90143-3
TL Litovitz W Klein-Schwartz GM Oderda BF Schmitz (1988) ArticleTitleClinical manifestation of toxicity in a series of 784 boric acid ingestions Am J Emerg Med 6 209–213 Occurrence Handle10.1016/0735-6757(88)90001-0
FJ Murray (1995) ArticleTitleA human health risk assessment of boron (boric acid and borax) in drinking water Regul Toxicol Pharmacol 22 221–30 Occurrence Handle10.1006/rtph.1995.0004
K O’Sullivan M Taylor (1983) ArticleTitleChronic boric acid poisoning in infants Arch Dis Child 58 737–739
CJ Price MC Marr CB Myeos JC Seely JJ Heindel BA Schwetz (1996) ArticleTitleThe developmental toxicity of boric acid in rabbits Fundam Appl Toxicol 34 176–187 Occurrence Handle10.1006/faat.1996.0188
BS Sayli E Tuccar AH Ellan (1998) ArticleTitleAn assessment of fertility in boron-exposed Turkish subpopulations Reprod Toxicol 12 297–304 Occurrence Handle10.1016/S0890-6238(98)00013-6
BS Sayli E Tüccar AH Ellan (2001) ArticleTitleAn assessment of fertility and infertility in boron-exposed Turkish subpopulations. 3. Evaluation of fertility among sibs and in “borate families” Bio Trace Element Res 81 255–267 Occurrence Handle10.1385/BTER:81:3:255
JS Schou JA Jansen B Aggerbeck (1984) ArticleTitleHuman pharmacokinetics and safety of boric acid Arch Toxicol Suppl 7 232–235
TR Shuler P Pootrakul P Yarnsukon FH Nielsen (1990) ArticleTitleEffect of thalassaemia/ immunoglobin E disease on macro, trace and ultratrace element concentrations in human tissues J Trace Elem Exp Med 3 31–43
RA Smith FM Ascherl (1999) ArticleTitleIssues concerning the measurement of borate in occupational environments Am Ind Hyg Assoc J 60 651–658
L Thomas C Krebs (1997) ArticleTitleA review of statistical power analysis software Bull Ecol Soc Am 78 126–139
DH Wegman EA Eisen X Hu SR Woskie RS Smith D Garabrandt (1994) ArticleTitleAcute and chronic respiratory effects of sodium borate particulate exposures Environ Health Perspectives 102 119–128
WHO. 1994 Assessing human health risks of chemicals: derivation of guidance values for health-based exposure limits. In: Environmental Health Criteria 170. Geneva, World Health Organization, IPCS
WHO. 1998a Guidelines for drinking-water quality. In: Health Criteria and Other Supporting Information, 2nd ed. Vol. 2. Geneva, World Health Organization
WHO. 1998b Boron. In: Environmental Health Criteria Monograph 204. Geneva, World Health Organization, IPCS. pp. 1–125
MD Whorton JL Haas L Trent O Wong (1994) ArticleTitleReproductive effects of sodium borates on male employees: birth rate assessment Occup Environ Med 51 761–767 Occurrence Handle10.1136/oem.51.11.761
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Yazbeck, C., Kloppmann, W., Cottier, R. et al. Health Impact Evaluation of Boron in Drinking Water: A Geographical Risk Assessment in Northern France. Environ Geochem Health 27, 419–427 (2005). https://doi.org/10.1007/s10653-005-1796-6
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DOI: https://doi.org/10.1007/s10653-005-1796-6